نتایج جستجو برای: induced mutation
تعداد نتایج: 1234912 فیلتر نتایج به سال:
Background and Aim: Jaundice is a common disorder in neonates and one of the provable causes of glucose-6-phosphate dehydrogenase (G6PD) deficiency, some mutation types of which may be associated with severe neonatal icter. In this line, the present study has been conducted to compare G6PD mutations in incteric and non icteric neonates. Materials and Methods: This case-control study was imple...
A heterozygous (het) gain-of-function (GoF) mutation (I1033M or I1040T) of TRPM4, a calcium-activated nonselective monovalent cation channel, has been reported as the cause progressive symmetric erythrokeratodermia. This genetic disease is characterized by red, scaly plaques in periorificial and acral regions that are reminiscent human psoriasis. To determine whether TRPM4 alone sufficient to l...
Special mechanisms of mutation are induced in microbes under growth-limiting stress causing genetic instability, including occasional adaptive mutations that may speed evolution. Both the mutation mechanisms and their control by stress have remained elusive. We provide evidence that the molecular basis for stress-induced mutagenesis in an E. coli model is error-prone DNA double-strand break rep...
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