Implementation intentions ("If I encounter Situation X, then I'll perform Behavior Y!") are postulated to instigate automatic action initiation. In 4 studies, the hypothesis was tested that implementation intentions lead to immediate action initiation once the specified situation is encountered, even under conditions of high cognitive load. First, individuals whose action control is known to be...

Treatment of cancer patients with chemotherapeutics like cyclophosphamide often causes alopecia as a result of premature and aberrant catagen. Because the epidermal growth factor receptor (EGFR) signals anagen hair follicles to enter catagen, we hypothesized that EGFR signaling may be involved in cyclophosphamide-induced alopecia. To test this hypothesis, skin-targeted Egfr mutant mice were gen...

Cellular sodium excess is cytotoxic because it increases both the intracellular osmotic load and intracellular calcium concentration ([Ca(2+)](i)). Because sodium levels rise during hypoxia, it is thought to contribute to hypoxic injury. Thus the present study tested the hypothesis that taurine-linked reductions in [Na(+)](i) reduce hypoxia-induced cell injury. Taurine depletion was achieved by...

Recent studies have implicated the involvement of Ca2+-dependent mechanisms, in particular, calcium/calmodulin-protein kinase II in nicotine-induced antinociception using the tail-flick test. The spinal cord was suggested as a possible site of this involvement. The present study was undertaken to investigate the hypothesis that the beta2 nicotinic receptor subunit plays a central role in nicoti...

Azarashvili T, Krestinina O, Galvita A, Grachev D, Baburina Y, Stricker R, Evtodienko Y, Reiser G. Ca -dependent permeability transition regulation in rat brain mitochondria by 2 ,3 -cyclic nucleotides and 2 ,3 -cyclic nucleotide 3 -phosphodiesterase. Am J Physiol Cell Physiol 296: C1428–C1439, 2009. First published April 8, 2009; doi:10.1152/ajpcell.00006.2009.—Recent evidence indicates that 2...

Learning vocabulary is a central and time-consuming endeavour for language learner it has thus been suggested that the foreign classroom to supply explicit support students’ development. A major source of word focus exercises in teaching materials learning can be facilitated if they are designed way conducive learning. Few studies have so far sought establish what opportunities tasks provide. T...

In normal isolated, perfused canine ventricles, increased ventricular volume leads to shortening of refractoriness. To test the hypothesis that myocardium within an infarction zone is more susceptible to volume-induced changes in refractoriness than is normal myocardium, we measured strength-interval curves at low and high end-diastolic volumes at control and infarcted sites in 14 isolated, blo...