objective: evaluating the effects of p-benzoquinone and hydroquinone on the runx2 expression and osteoblastic differentiation of human marrow derived mesenchymal stem cells (mscs). materials and methods: bone marrow mscs obtained by cultivating marrow mononuclear cells, were exposed to 10μm of either p-benzoquinone or hydroquinone. following chemical treatment, runx2 gene expression was assess...

The potential of many drugs and chemicals to cause prenatal harm is well-established. The types of effects seen vary and include spontaneous abortions, stillbirths, congenital malformations present at birth, and conditions detected only months to years after birth. Most studies designed to determine whether agents cause malformations have examined the effects of exposure of the embryo or fetus ...

a large body of evidence now indicates that the amount of mercury released from dental amalgam fillings can be significantly accelerated by exposure to radiofrequency electromagnetic fields (rf-emfs) such as common mobile phones and magnetic resonance imaging (mri). studies performed on the increased microleakage of dental amalgam restorations after exposure to rf-emfs have further supported th...

background: polycyclic aromatic hydrocarbons (pahs) such as naphthalene (nap) are organic pollutants that have spread widely in littoral marine ecosystems. we aimed to study the effect of acute and prolonged exposure to naphthalene (nap) on plasma cortisol and thyroid levels in mature and immature liza klunzingeri mulet. methods: in acute stress experiment, the treatment group received 2μl g-1 ...

introduction: doxorubicin is frequently used for treatment of several types of cancer. doxorubicin cardiac toxicity has limited the use of this drug. corticosteroids may prevent doxorubicin induced cardiotoxicity. therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of doxorubicin and dexamethasone. methods: mouse em...

background: the present study describes the susceptibility of prepubertal testis of mice to prooxidant induced oxidative impairments both under in vitro and in vivo exposure conditions. materials and methods: following in vitro exposure to iron (5,10 and 25 m), oxidative response measured in terms of lipid peroxidation and hydroperoxide levels in testis of pre pubertal mice (4 wk) was more robu...

objective: chlorpyrifos (cpf) is a neurotoxic organophosphorus (op) insecticide. its mechanism of action includes oxidative stress, excitotoxicity, and inhibition of the acetylcholinesterase enzyme (ache). the aim of the present study is to investigate cpf toxicity in mature and immature cerebellar granule neurons (cgns), as well as its effect on glutamate induced excitotoxicity. materials and ...

background : electromagnetic fields are associated with production, transmission and use of electricity. in this  tudy we have investigated the effects of short and long time alternative magnetic fields' (amf, 50 hz) exposure on the secretion of hypothalamic-pituitary-gonadal axis in the male rats. methods : forty eight wistar male rats, same range of age and weight were divided into four group...

background: this study was performed to investigate the adverse effects of acute lead intoxication on hemogram, erythrocyte osmotic fragility and oxidant/antioxidant status and the probable ameliorating effect of silymarin in comparison to d-penicillamine. methods: forty-eight albino rats were divided in 8 groups and received the following treatments in a 10 day experiment in shahid chamran uni...

occupational exposure to heavy metals, organic solvents and silica is associated with a variety of renal manifestations. improved understanding of occupational renal disease provides insight into environmental renal disease, improving knowledge of disease pathogenesis. silica (sio 2 ) is an abundant mineral found in sand, rock, and soil. workers exposed to silica include sandblasters, miners, q...