ObjectiveThe purpose of this study is to investigate the effect kaempferol (KAE), an effective constituent Buddleja officinalis, on human corneal epithelial cells (HCECs) under a hyperosmolar environment. Methods HCECs were cultured in DMEM/F12 medium and allocated into four groups: normal, model, vehicle, KAE. Ki67 staining was used detect HCEC proliferation; TdT-mediated dUTP Nick-End Labelin...

Endoplasmic reticulum (ER) stress can induce autophagy via the unfolded protein response (UPR), and regulate activation of inflammasomes. Inositol-requiring enzyme 1α (IRE1α) is a transducer UPR in cells with ER stress. Here, we investigated role IRE1α its impact on rheumatoid arthritis fibroblast-like synovial (RA-FLSs). RA-FLSs were isolated from (RA) patients stimulated thapsigargin (TG) to ...


 Purpose: To evaluate the role of miR-20a in sevoflurane (SEV)-induced cognitive impairment rats and to elucidate mechanism action.
 Methods: A SEV-induced rat model was developed. The Morris water maze test fear assay were carried out assess impaired learning memory. cellular SEV-impaired developed level measured animal models. TUNEL staining immunoblot performed determine SEV effec...

The present study aimed to explore the therapeutic effects of carvacrol on ulcerative colitis (UC) inflammation model induced by DSS (dextran sulfate sodium) in rats. Forty rats were randomly divided into blank, model, low-, middle-, and high-dose groups. drank 4.5% for 5 consecutive days induce UC except blank group. Different concentrations either or purified water supplied intragastric admin...

objective(s): 3,4-methylenedioxymethamphetamine (mdma) is one of the most popular drugs of abuse in the world with hallucinogenic properties that has been shown to induce apoptosis in  liver cells. the present study aimed to investigate the effects of pentoxifylline (ptx) on liver damage induced by acute administration of mdma in wistar rat. materials and methods: animals were administered with...

chamaemelum nobile (asteraceae) commonly known as 'roman chamomile' is a medicinal plant used for numerous diseases in traditional medicine, although its anticancer activity is unknown. the present study was carried out to investigate the anticancer as well as apoptotic activity of ethyl acetate fraction of c. nobile on different cancerous cell lines. the cells were treated with varyi...

objective(s):  chlorpyrifos (cp) is a broad-spectrum organophosphorus pesticide used extensively in agricultural and domestic pest control, accounting for 50% of the global insecticidal use. in the present study, protective effects of two selenium-enriched strong antioxidative medicines imod and angipars were examined in human lymphocytes treated with cp in vitro. materials and methods: isolate...

Summary: Burns are skin damage caused by heat trauma or cold (frost bite). Causes include fire, hot water, electricity, chemicals, radiation, and (frostbite). This may involve subcutaneous tissue. Burn injuries associated with high incidence prevalence, risk of morbidity mortality, resource-intensive, costly. One the most common complications in burn patients is acute kidney injury (AKI). The m...