noroviruses (novs), an important pathogenic agent of foodborne illness, lead to acute and chronic gastroenteritis in humans of all ages and to travelers’ diarrhea. many genotypes exist in nature; gii.4 is widely known as the most predominant. outbreaks mostly occur in semi-closed settings. although the disease is self-limited to person, many cases have resulted in death, which has raised more c...

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

epilepsy is a common neurologic disorder affecting approximately 1% of the population. the prevalence of active epilepsy in kerman,iran is 7.87/1000 individuals. the past decade has brought many advances to the treatment of epilepsy, including many new pharmacological agents. lamotrigine is one of the new antiepileptic drugs. lamotrigine has many side effects; the most important of which are al...