نتایج جستجو برای: import

تعداد نتایج: 23938  

Journal: :The Journal of clinical investigation 1993
M Wendland S Subramani

Cells from patients with peroxisome-deficient disorders contain membrane ghosts devoid of most matrix contents instead of normal peroxisomes indicating that the underlying molecular defects impair the import of matrix proteins into these peroxisome ghosts. Genetic heterogeneity for the molecular defects was inferred from the assignment of patients with peroxisome-deficient disorders into nine c...

2014
Jian Xu Qin Yao Wei Zhang Marc A. Rosen

In 2013, China imported 282 million tons of crude oil with an external dependence of 58.1%, surpassing the USA as the world’s largest net oil importer. An import source diversification strategy has been adopted by China to ensure oil supply security and to prevent oil supply disruption. However, the strategy is restricted by the imbalance of oil reserves. What is the reasonable and clear object...

Journal: :Biochemistry 2003
Konstantin Fineberg Tali Fineberg Adolf Graessmann Nathan W Luedtke Yitzhak Tor Rui Lixin David A Jans Abraham Loyter

The HIV-1 Rev protein plays a pivotal role in viral replication, and therefore, inhibition of its function should block the progression of the virus-induced immune deficiency syndrome (AIDS). Here, RNA molecules have been shown to inhibit import of the HIV-1 Rev protein into nuclei of permeabilized cells. Nuclear uptake of biotinylated recombinant His-tagged Rev-GFP was assessed in nuclear extr...

Journal: :The Journal of biological chemistry 2002
Courtney C Harper Sarah T South J Michael McCaffery Stephen J Gould

Of the approximately 20 proteins required for peroxisome biogenesis, only four have been implicated in the process of peroxisomal membrane protein (PMP) import: Pex3p, Pex16p, Pex17p, and Pex19p. To improve our understanding of the role that Pex17p plays in PMP import, we examined the behavior of PMPs in a Pichia pastoris pex17 mutant. Relative to wild-type cells, pex17 cells appeared to have a...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Samuel A Hasson Robert Damoiseaux Jenny D Glavin Deepa V Dabir Scott S Walker Carla M Koehler

The TIM22 protein import pathway mediates the import of membrane proteins into the mitochondrial inner membrane and consists of two intermembrane space chaperone complexes, the Tim9-Tim10 and Tim8-Tim13 complexes. To facilitate mechanistic studies, we developed a chemical-genetic approach to identify small molecule agonists that caused lethality to a tim10-1 yeast mutant at the permissive tempe...

Journal: :Molecular and cellular biology 2004
Antje Schäfer Daniela Kerssen Marten Veenhuis Wolf-H Kunau Wolfgang Schliebs

Within the extended receptor cycle of peroxisomal matrix import, the function of the import receptor Pex5p comprises cargo recognition and transport. While the C-terminal half (Pex5p-C) is responsible for PTS1 binding, the contribution of the N-terminal half of Pex5p (Pex5p-N) to the receptor cycle has been less clear. Here we demonstrate, using different techniques, that in Saccharomyces cerev...

Journal: :Plant physiology 2001
D Jackson-Constan K Keegstra

The process of protein import into plastids has been studied extensively using isolated pea (Pisum sativum) chloroplasts. As a consequence, virtually all of the known components of the proteinaceous apparatus that mediates import were originally cloned from pea. With the recent completion of the Arabidopsis genome sequencing project, it is now possible to identify putative homologs of the impor...

Mehdi Amini Rad, Mohammad Hassan Fotros Narges Ahmadvand,

Technology spillover from trade channel is important. Absorbing foreign technology by the channel of importation and using the latent technology in those products create export development, increase the quality and quantity of manufactured goods, and modify management, technology improvements and production of goods with high added value; this might favorise optimal allocation of resources. Imp...

2017
Christian D Peikert Jan Mani Marcel Morgenstern Sandro Käser Bettina Knapp Christoph Wenger Anke Harsman Silke Oeljeklaus André Schneider Bettina Warscheid

Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analysing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting our understanding of organellar biogenesis and function. Here we introduce a method that enables ch...

2003
Neal D. Freedman Keith R. Yamamoto Pamela Silver

The vertebrate glucocorticoid receptor (GR) is cytoplasmic without hormone and localizes to the nucleus after hormone binding. GR has two nuclear localization signals (NLS): NL1 is similar in sequence to the SV40 NLS; NL2 is poorly defined, residing in the ligand-binding domain. We found that GR displayed similar hormone-regulated compartmentalization in Saccharomyces cerevisiae and required th...

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