The rosette inhibition test was used to measure serum immunosuppressive activity after azathioprine (1.5 mg/kg) in 20 patients with liver disease (10 with active chronic hepatitis, six with primary biliary cirrhosis, and four with miscellaneous hepatic disorders) and in nine healthy normal volunteers. Where possible testing was repeated after one week and after at least two months of treatment....

In recent years, many new immunosuppressive drugs have been discovered and developed for clinical use in transplantation. This review focuses on those drugs (leflunomide, mycophenolate mofetil, sirolimus, tacrolimus) that have been shown to have immunosuppressive activity in patients. Different anti-interleukin-2 receptor antibodies are also reviewed as an example of a resurgence of development...

Immunosuppressive agents are commonly used in the prevention of graft rejection following transplantation and in the treatment of autoimmunity. In this study, we examined the immunosuppressive mechanism of the drug 15-deoxyspergualin (DSG), which has shown efficacy in the enhancement of graft survival and in the treatment of autoimmunity. Using a murine model of chronic relapsing and remitting ...

Drug-induced gingival hyperplasia is the increased growth of epithelium and submucosa which may cause bleeding loss teeth. Certain anticonvulsant, immunosuppressive, antihypertensive drugs are underlying in most cases. Among them, cases due to amlodipine very rare. Here, we discuss topic along with a case overgrowth induced by amlodipine. A 51-year-old female presented overgrowth. She was on be...

Purpose. The case of a kidney transplant recipient who experienced a probable drug interaction between sirolimus and ranolazine is reported. Summary. The narrow therapeutic window of immunosuppressive therapy in transplant recipients requires close monitoring for potential drug-drug interactions. The patient, a 57-year-old Caucasian male kidney transplant recipient, was stable for years on siro...

In the last decade, a paradigm shift has occurred in the field of renal transplantation. The use of new and powerful immunosuppressive drugs has led to excellent short-term patient and graft survival and very low acute rejection (AR) rates. Two burning questions have become paramount. The first is how can we improve long-term patient and graft survival despite the fact that more elderly patient...