نتایج جستجو برای: immunosuppressive agent

تعداد نتایج: 273767  

2017
Rory H. Gibson Richard Hotham Aleksandra Bojarczuk Amy Lewis Ewa Bielska Robin C. May Philip M. Elks Stephen A. Renshaw Simon A. Johnston

Anti-proliferative agents that target lymphoid cells are common immunosuppressive agents used in the treatment of diverse autoimmune, graft versus host and inflammatory diseases. Mycophenolate mofetil (MMF) is an anti-proliferative agent that targets lymphoid dependence on inosine monophosphate dehydrogenase for the de novo purine synthesis of deoxyguanosine triphosphate (dGTP) for DNA replicat...

Journal: :Clinical microbiology reviews 2004
Martin Rodriguez Jay A Fishman

Pneumocystis infection in humans was originally described in 1942. The organism was initially thought to be a protozoan, but more recent data suggest that it is more closely related to the fungi. Patients with cellular immune deficiencies are at risk for the development of symptomatic Pneumocystis infection. Populations at risk also include patients with hematologic and nonhematologic malignanc...

Journal: :Modern rheumatology 2010
Satoru Akazawa Kunihiro Ichinose Tomoki Origuchi Shin-ya Kawashiri Naoki Iwamoto Keita Fujikawa Toshiyuki Aramaki Makoto Kamachi Kazuhiko Arima Mami Tamai Hideki Nakamura Hiroaki Ida Atsushi Kawakami Katsumi Eguchi

A 36-year-old female patient who was diagnosed with chronic myocarditis as an initial manifestation of systemic lupus erythematosus (SLE) was admitted to our hospital. At her third occurrence of heart failure, we performed an endomyocardial biopsy and proved chronic myocarditis with SLE. Subsequently, she was treated with prednisolone and the immunosuppressive agent mizoribine (MZR), and her ca...

Journal: :Proceedings of the Royal Society of Medicine 1967

Journal: :Neurology 2016
Gregory Y Chang Altaf Saadi Jeremy D Schmahmann

• Tacrolimus is an immunosuppressive agent that inhibits the activity of calcineurin. Neurologic adverse effects are varied and manifest irrespective of tacrolimus levels. These can include minor headaches and tremor to more severe seizures, cortical blindness, and coma. • Tacrolimus-associated brainstem neurotoxicity is a rarely documented phenomenon that should be considered in the differenti...

Journal: :Digestive diseases and sciences 1994
N Singh L Mieles V L Yu T E Starzl

Cytomegalovirus (CMV) is a major infectious complication of organ transplantation and its incidence is influenced by the type and intensity of immunosuppressive therapy employed. Using a new immunosuppressive agent FK506, CMV infection was observed in 30% and CMV disease in 15% of the 26 liver transplant recipients. Delayed onset of CMV disease was noted; the mean time to the occurrence of CMV ...

Journal: :The Journal of Experimental Medicine 1994
S Urioste L R Hall S R Telford R G Titus

Tick-borne pathogens would appear to be vulnerable to vertebrate host immune responses during the protracted duration of feeding required by their vectors. However, tick salivary components deposited during feeding may inhibit hemostasis and induce immunosuppression. The mode of action and the nature of immunosuppressive salivary components remains poorly described. We determined that saliva fr...

Journal: :Neuroscience 2016
M Yousefifard V Rahimi-Movaghar F Nasirinezhad M Baikpour S Safari S Saadat A Moghadas Jafari H Asady S M T Razavi Tousi M Hosseini

Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum protocol has been developed for application of neural stem/progenitor cells. In this regard, the present meta-analysis showed that the efficacy of the neural stem/progenitor cell (NSPC) transplantation depends mainly on injury model, intervention phase, transplanted cell count, immunosuppressive use, and p...

Journal: :The Journal of antibiotics 1994
T Fujita K Inoue S Yamamoto T Ikumoto S Sasaki R Toyama K Chiba Y Hoshino T Okumoto

A potent immunosuppressive activity was found in the culture broth of the fungus Isaria sinclairii (ATCC 24400). The metabolite, ISP-I ((2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2- hydroxymethyl-14-oxoeicos-6-enoic acid, myriocin = thermozymocidin) suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction, but had no effect on the growth of human tumor cell lines. It ...

2015
KR Jyothi Jagadish Beloor Ara Jo Minh Nam Nguyen Tae Gyu Choi Jin-Hwan Kim Salima Akter Sang-Kyung Lee Chi Hoon Maeng Hyung Hwan Baik Insug Kang Joohun Ha Sung Soo Kim

Therapeutic options for hepatitis C virus (HCV) infection have been limited by drug resistance and adverse side effects. Targeting the host factor cyclophilin A (CypA), which is essential for HCV replication, offers a promising strategy for antiviral therapy. However, due to its immunosuppressive activity and severe side effects, clinical application of cyclosporine A (CsA) has been limited as ...

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