Introduction: Cancer is malignant disease, one of the leading cause deadth at global level. The determination origin tumors really essential for not only prognosis but also effective treatment orientation cancerous patients. Objective: Defining histopathological types epithelial and determining by CK7, CK20 other immunohistochemical markers. Patients methods: A cross-sectional study 50 patients...

background gastrointestinal stromal tumors (gists) are potentially malignant tumors; however their behavior and response to treatment is dependent on the type of mutation and immunohistochemical expression of antigens. it is recommended to perform routine molecular and immunohistochemical tests in kit and platelet derived growth factor receptor alpha (pdgfra) molecules for making decision regar...

Introduction: Most B-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. Some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. Molecular techniques can be used as a helpful diagnostic tool in these cases. In this study, we assessed the value of polymerase chain reaction (PCR) t...

Immunohistochemical demonstration of tumor-associated markers may be valuable as an adjunct to conventional histology for determination of malignancy development in oral mucosal diseases. Accordingly, the present study determined the distribution of some important tumor markers such as heat shock proteins (HSP), fibroblast growth factors (FGF) and transferrin receptors (TF-R) in 22 samples ...

BACKGROUND Learning and memory are the most intensively studied subjects in neuroscience. Two sites of mammalian brain which are important in learning and memory are CA1 region of hippocampus and Purkinje cell layer of cerebellum. So, the aim of present investigation was to study of the effect of ovariectomy and passive avoidance learning on NR1 subunit of N-methyl-D-aspartate (NMDA) receptor d...

INTRODUCTION Determination of the type of mutations in gastrointestinal stromal tumours (GIST) plays a major role in assessing the risk of progression of the disease, and also allows determination of the clinical management and treatment. More accurate GIST diagnosis is possible by using simultaneously various types of antibodies to immunohistochemistry methods in routine procedures. AIM To e...

PURPOSE Thalidomide, because of its anti-inflammatory properties, as re-emerged as an option for the treatment of Crohn's disease refractory to standard therapy. We studied the effect of thalidomide on the healing of colonic anastomosis. METHODS Sixty male rats (Rattus norvegicus), were divided into 3 groups of 20 animals each, respectively receiving 0.5 or 1.0 mg/kg thalidomide by the oral r...

CerbB2 receptor determination is very important for the prognosis and treatment of breast cancer. The most used two methods for CerbB2 receptor determination are immunohistochemistry and FISH methods. FISH method is recommended for immunohistochemically CerbB2 (++) patient group. Therefore, even though the immunohistochemically CerbB2 (++) patients are in the same group, FISH test divides the r...