A marked imbalance of the two light chain types of immunoglobulins was observed in two young male adults suffering from primary hypogammaglobulinemia and intrinsic factor-deficient pernicious anemia. In one patient, the i/A light chain ratio of serum immunoglobulins was 0.01; in the other it was approximately 6 (normal value, 1.8 ± 0.3). This light chain imbalance was found within each of the t...

The maternal immunoglobulins acquired through the colostrum play a significant role in the defense mechanism of lamb against neonatal diseases until its own immune system is primed and produces significant amount of antibodies. The absorption of these immunoglobulins from the intestine is maximum during first six hours of life and no absorption occurs 24-36 hours postpartum. Neonatal lambs with...

The purpose of this investigation was to study the distribution and levels of the following immunoglobulins, IgA, IgG, and IgM ,in sera and in some secretions of monkeys (M. fascicularis). IgG, IgA, and IgM were isolated from monkey serum and secretory IgA was separated from monkey milk by combined gel filtration and ion-exchange chromatography. These pure preparations served as standards to qu...

Acute renal failure is one of the side effects while using intravenous immunoglobulins. This complication is also observed with iodinated contrast media. Herein, we describe a patient with acute renal failure who received intravenous immunoglobulins and iodinated contrast media concomitantly. Both drugs are responsible for osmotic nephrosis. The same effect on renal cells may explain a synergis...

The occurrence of immunoglobulins with and without antibody specificity and with and without idiotypic specificity was studied, by use of enzyme-labeled antigen and antibodies, in lymph node cells of rabbits immunized with horse-radish peroxidase and hen ovalbumin. Some cells, containing immunoglobulins without detectable antibody function, were shown to contain idiotypes similar to those found...

Atomic force microscopy (AFM) techniques allowed us to visualize pentameric organization of immunoglobulins IgM and domain structure of immunoglobulins IgG. Together with obtained by AFM data on conditions of ribosome-inactivating proteins' type II (RIPsII) tetramerization these results contribute to many investigations concerning RIPsII biology as well as antigen-antibody and lectin-ligand int...

Immunoglobulins G, A, and M have been reponed to be present in statistically significant higher levels in diabetic patients compared to healthy comrols. II may be conceived that the levels of immunoglobulins might be significantly higher in diabetics with long-lasting (months of) poor control than in peers with an equally long term period of good control. To assess this possibility, we meas...