INTRODUCTION Immune function status is corresponded to genesis and progress of tumor, and cell immune plays a major role in anti-tumor immunity. In recent years, there has been more and more interest in the effect of tumor on functional imbalance of T lymphocyte subgroups. In order to study changes of immune status in colorectal cancer patients before and after operation, we determined six kind...

IMMU -21 a polyherbal immunomodulator effectively enhanced the immune status of animals treated with cytotoxic and immunosuppressive agents like cyclophosphamide and azathioprine. Leucopenia, lymphopenia and neutropenia in rats induced by cyclophosphamide were significantly minimized in IMMU-21 pre treated animals. IMMU-21 strengthened the host immune status against bacterial endotoxin. Cell me...

While many age-associated immune changes have been reported, a comprehensive set of metrics of immune aging is lacking. Here we report data from 243 healthy adults aged 40-97, for whom we measured clinical and functional parameters, serum cytokines, cytokines and gene expression in stimulated and unstimulated PBMC, PBMC phenotypes, and cytokine-stimulated pSTAT signaling in whole blood. Althoug...

Successfully identifying and targeting immune checkpoints on latently HIV-1-infected CD4 T cells could be a key component in HIV-1 eradication therapies [1,2]. Immune checkpoints are negative regulators of: (i) T cell activation; (ii) T cell proliferation; and (iii) effector functions including cytokine production [3]. Thus, inhibiting immune checkpoints could influence the resting status of la...

Introduction In vitro and animal studies have shown that hypoxia and hyperoxia influence the innate immune response. Therefore, hypoxia and hyperoxia could be cheap, non-pharmacological, non-invasive treatment modalities to modulate inflammatory conditions. Hypoxia has shown to exert pro-inflammatory effects, supposedly mediated by the transcription factor hypoxia inducible factor 1a (HIF1a), w...

artificial immune systems (ais) can be defined as soft computing systems inspired by immune system of vertebrates. immune system is an adaptive pattern recognition system. ais have been used in pattern recognition, machine learning, optimization and clustering. feature reduction refers to the problem of selecting those input features that are most predictive of a given outcome; a problem encoun...

Childhood leukemia, particularly acute lymphoblastic leukemia (ALL), has long been hypothesized to be affected by abnormal immune responses to microbial challenges stemming from a lack of immune modulation in early childhood. Studies of allergies suggest that a child's immune development may be modulated by maternal immune status. We conducted a study to explore the relationship between materna...

The relationship between nutritional status and the immune system has been a topic of study for much of the 20th century. Dramatic increases in our understanding of the organization of the immune system and the factors that regulate immune function have demonstrated a remarkable and close concordance between host nutritional status and immunity. This report traces the increasing sophistication ...

Protein-energy malnutrition decreases cellular immunity yet immune recovery has rarely been investigated during nutritional rehabilitation. Malnourished children from low income families of Cochabamba (Bolivia) were hospitalized for 2 months in the Center for Immune and Nutritional Rehabilitation (CRIN), of the German Urquidi Materno-Infantil Hospital. They received a special four-step diet. Nu...

The transition from late gestation to early lactation results in dramatic physiological changes including metabolic changes and immunosuppression in the dairy cow. As a result, cows are at a high risk for disease during this time. Evidence supporting a link between metabolic status and naturally occurring immunosuppression is growing. This review focuses on the impacts of metabolic status, and ...