In the adaptive immune response, the types of cytokines produced define whether there is a cellular (T1) or a humoral (T2) response. Specifically, in the T1 response, interleukin 2 (IL-2), interferon γ (IFN-γ) and tumor necrosis factor β (TNF-β) are produced, whereas in the T2 response, IL-4, IL-5, IL- 6, IL-10 and IL-13 are primarily produced. Cytokines are primarily involved in the regulation...

The cytotoxic host immune response toward autologous human cancer may be regulated by the immunoregulatory network. Here we show that helper T cells, cloned from peripheral blood lymphocytes that were sensitized in vitro against an autologous human malignant paraganglioma, proliferated against and made interleukin 2 when cocultured with the tumor-associated antigen in the presence of autologous...

The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored aft...

BACKGROUND Our recent investigations have demonstrated that cell cultures from subjects, who received a single spinal manipulative treatment in the upper thoracic spine, show increased capacity for the production of the key immunoregulatory cytokine, interleukin-2. However, it has not been determined if such changes influence the response of the immune effector cells. Thus, the purpose of the p...

a complete diet (total mixed ration) with sorghum stover (40%) as sole roughage source was prepared and offered to animals under two forms: as mash or as expanded-extruded pellets (eep). these two complete diets were compared with a conventional diet (ad libitum chopped sorghum stover fed separately with concentrate mixture to meet 80% of protein requirements). these three diets were randomly a...

a 42-day study was conducted to evaluate the influence of full-fat flaxseed (fs) and canola seed (cs) on broiler performance, fatty acid (fa) profile of meat, serum lipid content and antibody response to sheep red blood cells antigen (srbc). a total of 324 one-day-old chicks were attributed to 6 experimental groups. c: control (soybean-corn); cs1:7.5% cs; cs2:15% cs; cs-fs:10% fs + 10% cs; fs1:...

this study was conducted to determine the effects of adding ethanol extract of propolis (eep) and cumin essential oil (ceo) to diets of broiler chicks on the performance, blood parameters, immune response and carcass traits. a total of 240 day-old ross-308 broiler chicks were randomly allocated to four treatments with six replicates and 10 birds in each replicate in a completely randomized desi...

auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive t cells, and an inborn error of innate immunity. a narrative literature review was carried out of studies related to auto-inflammatory syndromes ...

background: myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. in many cases of sepsis, the presence of lipopolysaccharide (lps) has been established. lps binding protein (lbp) bound endotoxin is recognized by cd14/toll-like receptor-4 (tlr4) complexes in inna...

BALB/c mice infected with Leishmania major developed a type 2 immune response which failed to control parasite replication. We found that scid mice that received splenocytes from BALB/c mice that had been infected for 3 weeks with L. major (a type 2 cell population) and that were subsequently infected with L. major were protected when they were treated with interleukin 12 (IL-12). In contrast, ...