A 12 year old boy with eczema, asthma, and severe intolerance to cows' milk protein ate a small amount of food which contained casein. He developed a severe anaphylactic reaction, and within minutes he was dead.' After recent publicity of similar cases in the press, this is a scenario now greatly feared by parents of children with food intolerance. This article addresses two controversial issue...

Urticaria and angioedema are common allergic manifestations and medications are one of common triggering factors. The most severe immediate drug reaction is anaphylaxis. Apart from the well established IgE-mediated immediate type hypersensitivity reactions, the pathogenesis of drug-induced urticaria, angioedema and anaphylaxis often remains obscure. In this article, emphasis is put on nonallerg...

Protein contact dermatitis is a skin condition not well known and underdiagnosed by dermatologists, resulting from an IgE-mediated allergic reaction. Clinically it presents as a chronic hand and/or forearms eczema of occupational origin, especially in professionals who work as food handlers. Epicutaneous tests are negative, and to diagnose this condition it is necessary to perform immediate-typ...

The brain is thought to represent specific memories through the activity of sparse and distributed neural ensembles. In this review, we examine the use of immediate early genes (IEGs), genes that are induced by neural activity, to specifically identify and genetically modify neurons activated naturally by environmental experience. Recent studies using this approach have identified cellular and ...

Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage. By using in vivo two-photon imaging in neocortex, we found that microglial cells are highly active in their presumed resting state, continually surveying the...

The aim of the study was to establish influence a co-precipitation agent (i.e., NaOH–immediate precipitation; hexamethylenetetramine/urea–gradual precipitation and growth nanostructures) on properties catalytic activity as-synthesized Au-CeO2 nanocomposites. All catalysts were fully characterized with use XRD, nitrogen physisorption, ICP-OES, SEM, HR-TEM, UV-vis, XPS, tested in low-temperature ...

Excipient allergies are rare and difficult to diagnose. Carboxymethylcellulose (CMC, carmellose sodium) is an anionic water-soluble polymer derived from native cellulose, that is, used as excipient. Here, we report a case of urticaria caused by the CMC in lidocaine jelly dimethicone drops, which had for upper gastrointestinal endoscopy. widely pharmaceutical preparations, food additives, other ...