Brown, K. G. E., McMichen, H. U. S., and Briggs, D. S. (1972). Archives of Disease in Childhood, 47, 104. Tachyarrhythmia in severe imipramine overdose controlled by practolol. A 2a-year-old boy, comatose and having fits after an overdose of imipramine, suffered a respiratory and cardiac arrest from which he was successfully resuscitated. A severe tachyarrhythmia was well controlled by intraven...

Chloropromazine (CPZ) and imipramine at a concentration of 1 x 10(-3) M inhibit rat brain mitochondrial monoamine oxidase activity in vitro by 70 and 55% respectively, while lithium, even at a concentration of 0.05 M, inhibits the activity of this enzyme very negligibly (4%). In vivo, these drugs at a dose level of 56 mg CPZ, 76 mg imipramine and 76 mg lithium chloride/Kg body wt., did not caus...

Clinical observations suggest the involvement of nicotinic acetylcholine receptors (nAChRs) in depressive illness. There is no clear cut evidence that nicotine produces an antidepressant effect. The antidepressant effect was assessed by the forced swimming test using male albino mice. Nicotine (1.2 mg/kg s.c.) given 15 min. before the test exerted no effect on immobility. Given 30 min before th...

Quantitative autoradiography shows that there is a close relationship between [3H]imipramine binding sites and the distribution of 5-hydroxytryptamine (5-HT) neurons in the rat brain. High labeling is observed in the midbrain raphe nuclei, the areas of the dopamine cell groups of the substantia nigra and of the ventral tegmental area of Tsai, the ventral amygdaloid nucleus, the midline thalamic...

Zinc and magnesium are potent inhibitors of the NMDA receptor complex. Previous reports demonstrated that both zinc and magnesium, like other NMDA receptor antagonists, exhibit antidepressant-like effects in rodent screening tests. Moreover, chronic treatment with antidepressants and electroconvulsive shock increase zinc concentration in the rat hippocampus. The present study examined the effec...

This article addresses the management of depression in primary care from the perspective of a health maintenance organization. The rise of managed care systems is briefly discussed with reference to their impact on choice of treatment strategies. Cost-effectiveness considerations pertinent to a health maintenance organization are reviewed. A simplified protocol for the treatment of depression w...

BACKGROUND S-Adenosyl-L-methionine (SAMe), a natural compound, is the most important methyl donor in the central nervous system. In several clinical trials, SAMe showed antidepressant activity. OBJECTIVE Two multicenter studies were conducted in patients with a diagnosis of major depressive episode [baseline score on the 21-item Hamilton Depression Rating Scale (HAM-D) >or=18] to confirm the ...