Cyanide-catalyzed aldimine coupling was employed to synthesize compounds with 1,2-ene-diamine and alpha-imine-amine structural motifs: 1,2,N,N'-tetraphenyletheylene-1,2-diamine (13) and (+/-)-2,3-di-(2-hydroxyphenyl)-1,2-dihydroquinoxaline (17), respectively. Single-crystal X-ray diffraction provided solid-state structures and density functional theory calculations were used to probe isomeric p...

The complexation of (3aR,7aR)-N-(3,5-bis(trifluoromethyl)phenyl)octahydro-2H-benzo[d]imidazol-2-imine (BTI), as a guest, to ethane-bridged bis(zinc octaethylporphyrin), bis(ZnOEP), host, has been studied by means ultraviolet-visible (UV-Vis) and circular dichroism (CD) absorption spectroscopies, single crystal X-ray diffraction, computational simulation. formation 1:2 host-guest complex was est...

Methods for imine trifluoromethylation are of great importance because amines with trifluoromethylated stereogenic centers are useful building blocks for synthetic chemistry and drug discovery. Herein, we describe a new copper(II)-catalyzed imine trifluoromethylation method without the use of Lewis base activators, presumably through cooperative activation.

Borohydride reduction of a Borromean Ring (BR) complex containing six zinc(II) ions and 12 imine bonds has resulted in its demetallation, producing a neutral BR compound and also its free macrocycle, following cleavage of at least one of the imine bonds in the ethanolic reaction mixture.

Silica nanoparticles equipped with an artificial imine reductase display remarkable activity towards cyclic imine- and NAD(+) reduction. The method, based on immobilization and protection of streptavidin on silica nanoparticles, shields the biotinylated metal cofactor against deactivation yielding over 46 000 turnovers in pure samples and 4000 turnovers in crude cellular extracts.

A nickel-catalyzed cross-coupling amination with weak nitrogen nucleophiles is described. Aryl halides as well aryl tosylates can be efficiently coupled a series of N-nucleophiles, including anilines, sulfonamides, sulfoximines, carbamates, and imines via concerted paired electrolysis. Notably, electron-deficient anilines sulfonamides are also suitable substrates. Interestingly, when benzopheno...

In the mol-ecule of the title compound, C(14)H(12)FNO(2), the aromatic rings are oriented at a dihedral angle of 48.17 (1)°. An intra-molecular O-H⋯N hydrogen bond results in the formation of a six-membered ring. The title mol-ecule is a phenol-imine tautomer, as evidenced by the C-O [1.351 (3) Å], C-N [1.282 (3) Å], and C-C [1.416 (3)-1.445 (3) Å] bond lengths. In the crystal, mol-ecules are l...

In the asymmetric unit of the title compound, C(17)H(19)NO(3), there are three independent mol-ecules, which are align nearly parallel to each other and adopt the phenol-imine tautomeric form. In each mol-ecule, an intra-molecular O-H⋯N hydrogen bond results in the formation of an S(6) ring motif. The dihedral angles between the aromatic rings in the three independent mol-ecules are 13.55 (2), ...