BACKGROUND The lung is a frequent site of colorectal cancer (CRC) metastases. After surgical resection, lung metastases recurrences have been related to the presence of micrometastases, potentially accessible to a high dose chemotherapy administered via adjuvant isolated lung perfusion (ILP). We sought to determine in vitro the most efficient drug when administered to CRC cell lines during a sh...

Machine-generated documents containing semi-structured text are rapidly forming the bulk of data being stored in an organisation. Given a feature-based representation of such data, methods like SVMs are able to construct good models for information extraction (IE). But how are the featuredefinitions to be obtained in the first place? (We are referring here to the representation problem: selecti...

Insulin is one of the most studied proteins since it is central to the regulation of carbohydrate and fat metabolism in vertebrates and its expression and release are disturbed in diabetes, the most frequent human metabolic disease worldwide. However, the evolution of the function of the insulin protein family is still unclear. In this study, we present a phylogenetic and developmental analysis...

Inductive Logic Programming (ILP) is a sub-field of Machine Learning that provides an excellent framework for Multi-Relational Data Mining applications. The advantages of ILP have been successfully demonstrated in complex and relevant industrial and scientific problems. However, to produce valuable models, ILP systems often require long running times and large amounts of memory. In this article...

In Software-Defined Networking (SDN), the control and data planes are decoupled, leading to a more programmable efficient network management. this paper, controller placement problem in SDN is addressed, jointly with of exploring high-availability tree subgraph, order support delay availability requirements between switches controllers. We consider that each switch connects primary backup contr...

The distribution of free and liposomal doxorubicin (Liporubicin) administered by intravenous injection (IV) or isolated lung perfusion (ILP) was compared in normal and tumor tissues of sarcoma bearing rodent lungs. A single sarcomatous tumor was generated in the left lung of 35 Fischer rats, followed 10 days later by left-sided ILP (n=20) or IV drug administration (n=12), using 100 microg and 4...

BACKGROUND AND OBJECTIVE Simulation-based medical education (SBME) is used to teach residents. However, few studies have evaluated its clinical impact. The goal of this study was to evaluate the impact of an SBME session on pediatric interns' clinical procedural success. METHODS This randomized trial was conducted at 10 academic medical centers. Interns were surveyed on infant lumbar puncture...

We present a framework for the Induction of Functional Logic Programs (IFLP) from facts. This can be seen as an extension to the now consolidated field of Inductive Logic Programming (ILP). For that purpose we study the reversal of narrowing, the more usual operational mechanism for Functional Logic Programming. Also we fix the goal and heuristics in consilient programs rather than look for the...