نتایج جستجو برای: il18
تعداد نتایج: 258 فیلتر نتایج به سال:
BACKGROUND Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE We investigate if single nucleotide polymorphisms (SNP) in genes encoding cytokines, chemokines and...
BACKGROUND Juvenile idiopathic arthritis (JIA) consists of a heterogeneous group of disorders with, for the most part, an unknown immunopathogenesis. Although onset and disease course differ, the subtypes of JIA share the occurrence of chronic inflammation of the joints, with infiltrations of immunocompetent cells that secrete inflammatory mediators. OBJECTIVE To identify a panel of cytokines...
Persistent colonization with the gastric bacterial pathogen Helicobacter pylori causes gastritis and predisposes infected individuals to gastric cancer. Conversely, it is also linked to protection from allergic, chronic inflammatory, and autoimmune diseases. We demonstrate here that H. pylori inhibits LPS-induced maturation of DCs and reprograms DCs toward a tolerance-promoting phenotype. Our r...
We report an extended set of neuroimmunological data detected in cerebrospinal ̄uid (CSF) from n=267 patients with de®nite multiple sclerosis (MS). Known frequencies of oligoclonal IgG (98%), frequencies of intrathecal fractions of IgG, IgA and IgM (72%, 9% and 20%, respectively) were con®rmed and quantitated as intrathecal fractions, IgIF or CSF concentrations, IgLoc. Eighty-nine per cent of th...
Abstract Background Leptomeningeal disease (LMD) occurs in ~5% of patients with breast cancer (BC) and has a median survival 2-4 months. We found loss the anti-HER2 anti-HER3 CD4 Th1 immune responses BC patients. In pre-clinical clinical trials administration class II HER2 peptide-pulsed dendritic cell vaccine (HER2-DCV) partially restores pathologic complete HER2+ Here, we examined intrathecal...
Polymorphic light eruption (PLE) is a chronic intermittent skin disease that develops episodes after sun exposure, most often in spring or early summer. Although the pathogenesis not fully understood, evidence indicates microbiome may play crucial role. Preclinical data have shown can regulate UV-induced cytokine expression and modulate subsequent immune response. We therefore hypothesized of P...
BACKGROUND The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)-1β and IL-18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood. METHODS AND RESULTS Atherosclerotic plaques were analyzed for transcripts of the NLRP3...
BACKGROUND Many studies investigated the prognostic or predictive relevance of single nucleotide polymorphisms (SNPs) in biologically plausible genes in urinary bladder cancer (UBC) patients. Most published SNP associations have never been replicated in independent patient series. OBJECTIVE To independently replicate all previously reported associations between germline SNPs and disease progn...
Expression of genes associated with inflammation was analyzed during differentiation of human pluripotent stem cells (PSCs) to hepatic cells. Messenger RNA transcript profiles of differentiated endoderm (day 5), hepatoblast (day 15) and hepatocyte-like cells (day 21) were obtained by RNA sequencing analysis. When compared to endoderm cells an immature cell type, the hepatic cells (days 15 and 2...
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