نتایج جستجو برای: il17
تعداد نتایج: 451 فیلتر نتایج به سال:
The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells or Th17 cells impaired Th17 cell differentiation in vitro and in vivo, and led to resistance to autoimmune diseases. Mechanistically, CREB, activated by CD3-PKC-ϴ signaling, plays a key role in regu...
Tumor-infiltrating lymphocytes are key mediators of tumor immune surveillance and are important prognostic indicators in cancer progression. Among the various lymphocyte subsets implicated in protection against cancer are γδ T lymphocytes, which can kill tumor cells and secrete potent antitumor cytokines. By contrast, recent reports have revealed an unexpected series of protumor functions of γδ...
This study aimed to investigate the role of Pim-1 kinase in the regulation of naïve CD4+T cell differentiation. Naive CD4+T cells were isolated from the spleen of the mice and treated with different cytokines and Pim-1 kinase inhibitor. The expression of T-bet, GATA3, FOXP3 and RORγt proteins in naïve CD4+T cells was detected by Western blot analysis. The expression of cytokines IL-4, TGF-β, IF...
Pemphigus foliaceus (PF) is an autoimmune blistering disorder, mediated by autoantibodies against desmoglein 1 (Dsg1). It manifests with erosions and later on erythematous hyperkeratotic plaques/crusts without mucosal involvement.1 Few reports exist the coexistence of PF other diseases.2 Specifically, a higher prevalence plaque psoriasis (PP) has been reported among pemphigus patients.2 In psor...
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