The adrenal gland secretes several cytokines, and cytokines modulate steroid secretion by this gland. In this study, a survey of cytokine production by H295R human adrenocortical cells demonstrated that these cells secreted IL-2, IL-4, IL-8, IL-10, IL-13, and TNFalpha but not IL-5, IL-12, or interferon-gamma. IL-8 was the IL secreted at higher concentration. IL-8 secretion, its regulation, and ...

Pilomatricoma is a rare benign tumor of the hair follicle matrix cells, which associates during its evolution a foreign body-like inflammatory process. We have investigated three such tumors, two of them displaying a rather poor stroma, while the third was distinctive due to its stroma and large numbers of inflammatory cells infiltrating the tumor. The analysis of IL-8 (interleukin-8), CXCR1 (I...

Complex interactions exist between cytokines, and the interleukin family plays a fundamental role in inflammation. Particularly circulating IL-1β, IL-6 and IL-8 are unregulated in systemic and chronic inflammatory conditions. Hypercoagulability is an important hallmark of inflammation, and these cytokines are critically involved in abnormal clot formation, erythrocyte pathology and platelet hyp...

Mục tiêu: Nghiên cứu nồng độ IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, TNF-α, INF-γ trong bệnh vảy nến đỏ da toàn thân (VNĐDTT) tại Bệnh viện Da liễu Trung ương. Đối tượng và phương pháp nghiên cứu: Tiến cứu, mô tả cắt ngang có đối chứng so sánh với 30 nhân VNĐDTT (nhóm bệnh-NB) không chống chỉ định dùng Methotrexate người khỏe mạnh chứng-NĐC) tương đồng về tuổi giới. Kết quả: Trước điều trị: Nhóm ...

IL-8 or CXCL8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. Estrogen is crucial in breast carcinogenesis and tumor progression. Whether sex steroids affect IL-8 secretion of normal breast tissue or breast cancer is not known. Several cell types in a tissue secrete IL-8. Hence, regulatory mechanisms of IL-8 need to be investigated in whole tissue. ...