Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 MoAb induced only transiently expressed, small amounts of IL-2 mRNA that was com...

IL-36Ra, a member of the IL-1 family, is an antagonist IL-36 receptor and inhibitory regulator cascade. Loss function mutations in IL36RN gene, which encodes have been demonstrated to enhance cascade subsequently activation MAPK NF-κB pathways, resulting neutrophil recruitment pustule formation skin by increased production chemokines such as IL-8 CXCL-1. Cutaneous inflammation caused dysregulat...

BACKGROUND AND PURPOSE Smoking acts as a pro-inflammatory stimulus. Inflammation may provide a key mechanism by which smoking causes atherosclerosis. If so, then the degree to which an individual mounts an inflammatory response is likely to influence atherosclerosis severity. This study examined the impact of inflammatory gene polymorphisms and gene-smoking interactions on common carotid artery...

The long terminal repeat (LTR) of the human immunodeficiency virus (HIV) drives highly efficient gene expression in the presence of the transactivator, Tat. Thus, tat-containing vectors may be very useful tools in gene therapy. However information about the optimal way of delivering the tat gene is limited. In this study, we compared the effects of cis and trans expressions of the tat gene and ...

knowing that adenoviral vectors could initiate innate immunity, the ability of e1-deleted recombinant adenovirus (ad-e1δ) in induction of b7.1 and il-2 molecules was studied. methods: the expression of green fluorescent protein in c1498 cells following transfection of these cells with adenovirus green fluorescent protein vector confirmed the ability of adenovirus vectors in infecting the cells ...

objective(s) recombinant adenoviruses are currently used for a variety of purposes, including in vitro gene transfer, in vivo vaccination, and gene therapy. ability to infect many cell types, high efficiency in gene transfer, entering both dividing and non dividing cells, and growing to high titers make this virus a good choice for using in various experiments. in the present experiment, a reco...

gene polymorphism of cytokines influencing their function has been known as a contributing factor in the pathogenesis of inflammatory diseases of the tooth and implant supporting tissues. the aim of this study was to investigate the association of il-17r gene polymorphism (rs879576) with chronic periodontitis and periimplantitis in an iranian population. 73 patients with chronic periodontitis, ...