Numerical methods for partial differential equations in high-dimensional spaces are often limited by the curse of dimensionality. Though the sparse grid technique, based on a one-dimensional hierarchical basis through tensor products, is popular for handling challenges such as those associated with spatial discretization, the stability conditions on time step size due to temporal discretization...

Implicit integration factor (IIF) method, a class of efficient semi-implicit temporal scheme, was introduced recently for stiff reaction-diffusion equations. To reduce cost of IIF, compact implicit integration factor (cIIF) method was later developed for efficient storage and calculation of exponential matrices associated with the diffusion operators in two and three spatial dimensions for Cart...

Background We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America (El Bagre-EPF, or pemphigus Abreu-Manu). El Bagre-EPF differs from other types of EPF clinically, epidemiologically, immunologically and in its target antigens. We reported the presence of patient autoantibodies colocalizing with armadillo repeat gene deleted in velo-cardio-facia...

The type II restriction endonuclease SsoII shows sequence similarity with 10 other restriction endonucleases, among them the type IIE restriction endonuclease EcoRII, which requires binding to an effector site for efficient DNA cleavage, and the type IIF restriction endonuclease NgoMIV, which is active as a homotetramer and cleaves DNA with two recognition sites in a concerted reaction. We show...

Antineutrophil cytoplasmic antibody (ANCA) tests are used to diagnose and monitor inflammatory activity in Wegener granulomatosis, microscopic polyangiitis and its renal-limited variant (pauci-immune crescentic glomerulonephritis), and Churg-Strauss syndrome. The International Consensus Statement on testing and reporting of ANCA states that ANCA are demonstrated most readily in these conditions...

In order to diagnose chlamydiosis caused by bacteria Chlamydophila sp., the humoral immunity response in domestic bovines was examined. A possible difference in titre of specific antibodies between latently, acutely and chronically infected animals was also studied. At the same time we confirmed the applicability and reliability of complement-fixation tests (CFT) and enzyme–linked immunosorbent...

Examination of antinuclear antibody (ANA) is used in diagnosis systemic autoimmune diseases, and the indirect immunofluorescence (IIF) assay using HEp-2 cells gold standard method. allows detection multiple target antigen-directed autoantibodies. The guide “The International Consensus on ANA Patterns (ICAP)”, characterizes patterns into three groups: nuclear, cytoplasmic, mitotic. majority thes...

A Solar Radio Burst (SRB) is one of the most severe natural hazards affecting performance global navigation satellite systems (GNSS). Considering influence different threat factors, GNSS developers upgrade to amend accuracy and noise-proof features systems. In particular, GPS gradually replaces “old” satellites (GPS IIA, IIR-A, IIR-B) with new-generation equipment IIR-M, IIF, III) featured by a...

In this paper we address the issue of classifying the fluorescent intensity of a sample in Indirect Immuno-Fluorescence (IIF). Since IIF is a subjective, semi-quantitative test in its very nature, we discuss a strategy to reliably label the image data set by using the diagnoses performed by different physicians. Then, we discuss image pre-processing, feature extraction and selection. Finally, w...