Susanne Kircher, Institute of medical Chemistry, Währingerstr. 10, A-1090 Vienna (Austria) Dear Sir, Acid glycosaminoglycans (AGAG) have been implicated in the selective glomerular filtration of proteins, but so far their specific function has remained elusive. In 1978, Kanwar and Farquhar [1] reported the presence of AGAG in the glomerular basement membrane (GBM). Further studies showed that h...

Background and objectives Children with nephrotic syndrome can develop life-threatening complications, including infection and thrombosis. While AKI is associated with adverse outcomes in hospitalized children, little is known about the epidemiology of AKI in children with nephrotic syndrome. The main objectives of this study were to determine the incidence, epidemiology, and hospital outcomes ...

the hematological malignancies associated with nephrotic syndrome are mainly hodgkin’s and non-hodgkin’s lymphomas and chronic lymphocytic leukemia. acute myelogenous leukemia (aml) has rarely been described in associated with nephritic syndrome. we report a rare case of acute myelogenous leukemia who presented with nephrotic syndrome. a previously healthy 62-year-old man was admitted in nephro...

BACKGROUND The putative humoral mediator thought to be involved in the pathogenesis of idiopathic nephrotic syndrome has not yet been identified. However, components exist in normal serum that block the permeability activity of FSGS serum in vitro. The potential of FSGS serum to increase glomerular albumin permeability may result from an imbalance between permeability factors and naturally occu...

Introduction: Collapsing glomerulopathy is a severe podocyte injury that causes massive proteinuria, renal failure and is resistant to therapy. This disease is most often seen in association with HIV infection. However a growing list of collapsing glomerulonephropathy has been reported to occur in association with other infections, drugs, autoimmune diseases or is classified as idiopathic. Case...

Idiopathic membranous nephropathy (iMN) is a common cause of nephrotic syndrome in adults. A biomarker to accurately indicate the severity of iMN and predict long-term prognosis is insufficient. Here, we evaluated the clinical significance of circulating tumor necrosis factor receptors (cTNFRs) as prognostic biomarkers of iMN with nephrotic syndrome. A total of 113 patients with biopsy-proven i...

INTRODUCTION Membranous nephropathy (MN) in the context of rheumatoid arthritis (RA), is often an iatrogenic complication due to the nephrotoxic effects of antirheumatic drugs. Rare cases of non-iatrogenic association between these two diseases were reported in the literature. CASE REPORT A 30-year-old female patient presented in September 2005 with nephrotic syndrome. Renal biopsy showed fea...

Approximately 10-20% of children and 40% of adults with idiopathic nephrotic syndrome are steroid resistant and progress to end-stage renal disease requiring dialysis or renal transplantation. In these cases, renal histology typically shows focal segmental glomerulosclerosis. Mutations in NPHS1, NPHS2, WT1, CD2AP and ACTN4 genes located on different chromosomes, expressed by glomerular podocyte...