Abstract: Introduction: In present situation infertility is one of the chief problem for reproductive couples due to multiple factors including lifestyle. Infertility thought be caused by both male and female in 27 percent cases, with 15 cases being idiopathic. Assisted technologies are used these overcome problems related infertility, but success rate ART appreciated WHO if it reaches 30%. Abo...

background: high level of semen reactive oxygen species is considered as an important factor in male infertility. sesame has antioxidant properties, which could be effective on improvement of semen parameters. this study was designed to determine the effects of sesame on sperm quality.   materials and methods: twenty‑five infertile men entered this clinical trial. they were treated with a 3â€...

Small RNA has become a crucial regulator of protein synthesis during spermatogenesis. Alterations in small RNA function prove to be detrimental to proper spermatogenesis. As many patients suffer from idiopathic infertility, understanding the molecular mechanisms of small RNA identifies possible causes of certain types of infertility. With a comprehensive review of the history of miRNA and piRNA...

BACKGROUND Male factor and idiopathic infertility contribute significantly to global infertility, with abnormal testicular gene expression considered to be a major cause. Certain types of male infertility are caused by failure of the sperm to activate the oocyte, a process normally regulated by calcium oscillations, thought to be induced by a sperm-specific phospholipase C, PLCzeta (PLCζ). Prev...

background: the etiologic cause in near one third of male factor infertility is unknown. the percentage of men with idiopathic infertility who have been successfully treated by the empirical therapeutic modalities is not high. objective: the aim of this study was to assay the effect of l-carnitine on sperm parameters in patients who needs intracytoplasmic sperm injection (icsi) as a method for ...

background: although intrauterine insemination (iui) is one of the most common methods which is used for male factor and unexplained infertility the relative influence of various semen parameters on the likelihood of a successful outcome is controversial. several semen parameters have been evaluated as predictors of a successful outcome with intrauterine insemination. objective: to evaluate the...

Recent studies have shown significant associations of aberrant DNA methylation in spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions and imprinting disorders. Thus, the analysis of DNA methylation of specific genes in spermatozoa has the potential to become a new valuable diagnostic marker in clinical andrology. This perspective article discusses the curr...

Male factor infertility is a complex disorder, affecting approximately 10-15% of couples worldwide, however many of its aetiologies are unknown [1,2]. With the advent of assisted reproductive technology (ART), men with sub-optimal sperm quality are now able to overcome natural selection mechanisms and produce viable offspring [3]. Since ART is a relatively new phenomenon, the impact of inherita...

PRMT6, PEX10 and SOX5 genetic variants were identified as male infertility-associated loci in a genome-wide association study further validated various populations. Still, the results of previous case-control studies varied, which could be due to differences participants? ethnic backgrounds. The main purpose present was evaluate supposed these with idiopathic infertility North Macedonian popula...

Infertility is a problem affecting an increasing number of couples worldwide. Currently, marker tests for male factor infertility are complex, highly technical and relatively subjective. Up to 40% cases currently diagnosed as idiopathic therefore, there clear need further research into better ways diagnosing it. Changes in sperm telomere length have been associated with closely linked DNA damag...