BACKGROUND Herniated lumbar discs can induce sciatica by mechanical compression and/or chemical irritation. It was recently reported that neuroglial cellular activity after pulsed radiofrequency (PRF) application to a single dorsal root ganglion (DRG) attenuated neuroglial activity at the corresponding spinal dorsal horn. Recently, caudal epidural PRF has been used to manage neuropathic pain, b...

Activation of the sigma-1 receptor (Sig-1R) improves functional recovery in models of experimental stroke and is known to modulate microglia function. The present study was conducted to investigate if Sig-1R activation after experimental stroke affects mediators of the inflammatory response in the ischemic hemisphere. Male Wistar rats were subjected to transient occlusion of the middle cerebral...

Microglia activation in the spinal cord play a major role pathogenesis of neuropathic pain. The p38 mitogen-activated protein kinase (MAPK) regulates microglia activation. Previously, 2′,3′-dideoxycytidine (ddC), nucleoside reverse transcriptase inhibitor (NRTI), was found to induce mechanical allodynia and cords male female mice. In this study, we investigated MAPK signaling development using ...

GliaVolume 71, Issue 1 p. C1-C1 COVER IMAGEFree Access Cover Image, Volume First published: 21 November 2022 https://doi.org/10.1002/glia.24194AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use check box below share version article.I have read accept the Wiley Online Li...

Methamphetamine (Meth) is recognized as one of the most important new distributedabused drug that causes severe damage to the different parts of the brain, especiallyhippocampus. Previous studies have demonstrated that Meth can induce apoptosis and celldeath in the brain. In this study, we evaluated the long-term effects of Meth abuse in theCA1 region of postmortem hippo...

Like humans, horses are susceptible to neurotropic and neuroinvasive pathogens that not always readily identified in histological sections. Instead, alterations astrocytes microglia cells can be used as pathological hallmarks of injured nervous tissue a variety infectious degenerative diseases. On the other hand, equine glial cell poorly characterized Therefore, this study, we provide statistic...

Methamphetamine (Meth) is recognized as one of the most important new distributedabused drug that causes severe damage to the different parts of the brain, especiallyhippocampus. Previous studies have demonstrated that Meth can induce apoptosis and celldeath in the brain. In this study, we evaluated the long-term effects of Meth abuse in theCA1 region of postmortem hippo...

Mycoplasma ovipneumoniae is a respiratory pathogen that impacts domestic sheep (Ovis aries; DS) and bighorn canadensis; BHS). BHS are reported to be more susceptible than DS developing polymicrobial pneumonia associated with M. infection. Using formalin-fixed paraffin-embedded tissues, we performed retrospective study investigating the pulmonary immune response of infected exhibited robust well...