abstract: objective: giant cell tumor of soft parts is a rare neoplasm that mainly affects adulst and the elderly and is usually located in the extremities. here we report a child with giant cell tumor of soft tissue, which is a very rare condition in childhood. clinical presentation: a 5 year old girl presented with a 5 month history of left lower extremity pain. she had developed paraplegia b...

The human promyelocytic leukemia cell line HL-60 can be induced to differentiate into macrophage-like cells by nanomolar concentrations of phorbol esters. A phorbol ester-resistant var iant R1B6 obtained by culturing HL-60 cells with increasing concentrations of 12-O-tetradecanoylphorbol-13-acetate, is reversibly resistant. These cells have been growing continuously in the presence of phorbol e...

Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...

  Two rare cases of extra-articular diffuse variant giant cell tumor of the tendon sheath are presented, at the elbow of a 68-year-old female and the foot of a 56-year-old male. Both patients presented with a palpable masses and marginal excision was performed; histological sections confirmed the diagnosis of extra-articular giant cell tumor. No adjuvant therapy was administered. At the last fo...

leiomyoma is a very rare intraocular tumor, which can occur in the iris, ciliary body and choroids. we report a case of choroidal leiomyoma in a 16-years old women whose left eye was enucleated because of clinical suspicion for melanoma. using conventional light microscopy tumor was interpreted as spindle cell tumor, most probably of neurogenic origin and after using immunohistochemical studies...

introduction: primary gastric lymphoma (pgl) is a rare tumor, whose differential diagnosis may become complicated without precise immunohistochemistry (ihc) and genetic analysis. case presentation: a 33-year-old woman presented with gastric cancer and had undergone gastrectomy without precise ihc and staging in another center. inappropriate ihc after surgery showed diffuse large b-cell lymphoma...

conclusions prognosis of this type of tumor, apart from its size and differentiation level, depends on infiltration in tumor-surrounding tissue, perineural and perivascular spread. therefore, it is always necessary to analyze the removed skin especially on margins. introduction squamous cell carcinoma is the most common type of lip and oral cavity cancers. in majority of cases it follows quite ...

the p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. pancreatic tumor cells show a very high frequency of p53 mutation. to determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, panc-1 and htb80, differing in p53 status were stably transfected with exogenous wil...

abstract background: asterocytoma is the most common primary human brain tumor which has the most lethal hazard among tumors in human central nervous system. heat shock proteins play an active role in cancer cells pathways through their effects on tumor cell proliferation, tumor differentiation, malignancy, metastasis, and cell death. hsp 70 is a 70 kd protein that its expression change has bee...