Crystals of recombinant CloQ (subunit MW = 35 626 Da; 324 amino acids), an aromatic prenyltransferase from Streptomyces roseochromogenes, were grown by vapour diffusion. The protein crystallizes in space group I4(1)22, with unit-cell parameters a = b = 135.19, c = 98.13 A. Native data from a single crystal were recorded to a resolution of 2.2 A in-house. Preliminary analysis of these data indic...

Three ordered structures of the tetragonal BaAl4 type were identified in the Ba-Au-Sn system, from which a unified view of the interplay between the valence electron counts (VECs) and phase stabilities of these three types of derivatives can be developed. The BaNiSn3 (I4mm), ThCr2Si2 (I4/mmm), and CaBe2Ge2 (P4/nmm) type BaAu(x)Sn(4-x) phases occurred respectively at x = 0.78(1)-1, 1.38(1)-1.47(...

We explored the B-C-O system at pressures in the range 0-50 GPa by ab initio variable-composition evolutionary simulations in the hope of discovering new stable superhard materials. A new tetragonal thermodynamically stable phase B4CO4, space group I4[combining macron], and two low-enthalpy metastable compounds (B6C2O5, B2CO2) have been discovered. Computed phonons and elastic constants show th...

Cystathionine γ-synthase (CGS) catalyzes the first step in the transsulfuration pathway leading to the formation of cystathionine from O-succinylhomoserine and L-cysteine through a γ-replacement reaction. As an antibacterial drug target against Xanthomonas oryzae pv. oryzae (Xoo), CGS from Xoo (XometB) was cloned, expressed, purified and crystallized. The XometB crystal diffracted to 2.4 Å reso...

I4 An interpretation for the basic logic DW is 〈W,N,N,R,R, h〉 where W is a set of worlds; N,N ⊆ W are normal worlds for truth and non-falsity respectively; R,R ⊆ W 3 are access relations for truth and non-falsity respectively; and h is a function which assigns 1 or 0 to each /p/ at each w ∈ W . When hw(/p/) = 1 we say /p/ holds at w and otherwise fails. As a constraint on interpretations we req...

The electrical conductivity, U, and thermoelectric power, S , of the solid solutions (Dy,Y,-x)2M0207 have been measured in the temperature range 300-10 K. Log(aT) versus 1/T and S versus 1/T plots were found to be linear down to about 100 K. The activation energies E, and Es obtained from conductivity and thermoelectric power measurements, respectively, differ by one order of magnitude, indsati...

In recent years, it has been proved that vitamin K has important roles not only in blood coagulation but also in bone metabolism.i-i4) There are two types of vitamin K isolated from nature, vitamin Ki Cphylloquinone) synthesized mainly by plants, and vitamin K2 (menaquinone) rnade mainly by rnicroorganisms. Furthermore, there are fourteen kinds of menaquinone, depending upon the chain length of...

The substantial number of patients admitted to hospital with acute myocardial infarction often presents a problem in terms of bed occupancy, particularly in acute receiving wards after the initial period of intensive monitoring. The suggestion by Rose (I972) of a period of less than I4 days as an appropriate length of stay in hospital for patients with uncomplicated but definite myocardial infa...