In 1 9G2 Dr. C. M. Ross had started a pilot leprosy control proj ect in Samia district and he intended to study the effect of BCG vaccination on leprosy . The work of this devoted and conscientious leprologist was broken off by his death in 1 964. The data of his surveys mentioned in this article are derived from his original notes . In 1 962 Ross examined 1 7 7 children in schools at Buholo, C...

In leprosy, an infection produced by a mycobacterium, M. leprae, which is an obligatory intracellular parasite, it is the cell-mediated immunologic phenomena which intervene as defensive mechanisms, and not circulating antibodies. A high proportion of the general population is immune to the disease. It seems that in each generation there is a small group of persons susceptible to infection who ...

Histoid leprosy is a rare multibacillary form that presents with disseminated papule-nodular cutaneous lesions. To study the inflammatory infiltrate of the histoid form and to compare it with other lepromatous forms, we performed histological and immunohistochemical analysis on skin biopsies. Fifteen patients were included for histopathological analysis (10 histoid and five lepromatous) via the...

Erythema nodosum leprosum (ENL, Type 2 reactions) complicates lepromatous and borderline lepromatous leprosy and can affect many organ systems, often with irreversible damage. The reactions commonly occur in the 2 years after starting treatment and often run a recurrent or chronic course, sometimes for many years. Even with WHO multi-drug therapy about 30% of LL patients experience ENL. We revi...

Lepromin, a product containing Mycobacterium leprae from patients' tissues, fails to elicit skin reactions in lepromatous patients; this non-reactivity was utilized as a means of identifying the mycobacterium isolated in mouse foot-pads from leprosy patients. To do this a suspension of acid-fast bacilli prepared from mouse foot-pads infected with a typical isolate was compared to human lepromin...