AIM Acute hypobaric hypoxia is well known to alter brain circulation and to cause neuropsychological impairment. However, very few studies have examined the regional changes occurring in the brain during acute exposure to extreme hypoxic conditions. METHODS Regional cerebral blood flow (rCBF) response to hypoxia was investigated in six healthy subjects exposed to either normobaric normoxia or...

The nitric oxide (NO)-cGMP signal transduction pathway plays an important role in the regulation of pulmonary vascular tone and resistance in pulmonary hypertension. A number of studies have demonstrated that endothelial (e) and inducible nitric oxide synthases (NOS) are upregulated in hypoxia-exposed rat lung. These changes in NOS expression have been found to correlate with the process of pul...

Mechanism responsible for the enlargement of end-expiratory lung volume (EELV) induced by chronic hypoxia remains unclear. The fact that the increase in EELV persists after return to normoxia suggests involvement of morphological changes. Because hypoxia has been also shown to activate lung mast cells, we speculated that they could play in the mechanism increasing EELV similar role as in vessel...

The emergence of a new hypoxic therapy regimen in which intervals alternate with hyperoxic (30 % O2) led to the need study effectiveness hypoxic-hyperoxic for treatment progressive myopia. An ophthalmologic was performed on 116 male patients from 8 21 years age severe Doppler cerebral vessels, determination indices functional respiratory system were carried out. Interval hypoxia-hyperoxia prove...

5 Charles S. Fulco, Stephen R. Muza, Beth Beidleman, Robby Demes, 6 Janet Staab, Juli Jones, Allen Cymerman 7 8 Thermal and Mountain Medicine Division 9 10 November 2010 11 U.S. Army Research Institute of Environmental Medicine 12 Natick, MA 01760-5007 13 14 RUNNING HEAD: Normobaric hypoxia pre-treatment and altitude exposure 15 CORRESPONDING AUTHOR: 16 Charles S. Fulco, Sc.D. 17 Thermal and Mo...

Acute mountain sickness (AMS), characterized by headache, nausea, fatigue, and dizziness when unacclimatized individuals rapidly ascend to high altitude, is exacerbated by exercise and can be disabling. Although AMS is observed in both normobaric (NH) and hypobaric hypoxia (HH), recent evidence suggests that NH and HH produce different physiological responses. We evaluated whether AMS symptoms ...