نتایج جستجو برای: hypoxia ischemia

تعداد نتایج: 133254  

Journal: :The European journal of neuroscience 2006
Lir-Wan Fan Shuying Lin Yi Pang Philip G Rhodes Zhengwei Cai

To investigate whether minocycline provides long-lasting protection against neonatal hypoxia-ischemia-induced brain injury and neurobehavioral deficits, minocycline was administered intraperitoneally in postnatal day 4 Sprague-Dawley rats subjected to bilateral carotid artery occlusion followed by exposure to hypoxia (8% oxygen for 15 min). Brain injury and myelination were examined on postnata...

2014
SALIH KALAY OSMAN ÖZTEKIN GÖNÜL TEZEL HAKAN ALDEMIR EMEL SAHIN SADI KÖKSOY MUSTAFA AKÇAKUŞ NIHAL OYGUR

The objective of the present study was to evaluate the neuroprotective effects of immunoglobulin (Ig) in a neonatal hypoxic ischemic (HI) rat model. Seven-day-old rat pups were randomly assigned to control, hypoxia and hypoxia + Ig groups. The rats in the hypoxia +Ig group were intraperitoneally administered 1 g/kg Ig once, immediately after hypoxia. Saline was administered to the rats in the h...

2014
Karolina Skowronki Joseph Andrews David I. Rodenhiser Brenda L. Coomber

DNA hypomethylation is an important epigenetic modification found to occur in many different cancer types, leading to the upregulation of previously silenced genes and loss of genomic stability. We previously demonstrated that hypoxia and hypoglycaemia (ischemia), two common micro-environmental changes in solid tumours, decrease DNA methylation through the downregulation of DNMTs in human color...

2014
Prabhu Ramamoorthy Honglian Shi

Introduction: Pyramidal (glutamatergic) neurons and interneurons are morphologically and functionally well defined in the central nervous system. Although it is known that glutamatergic neurons undergo immediate cell death whereas interneurons are insensitive or survive longer during cerebral ischemia, the protection mechanisms responsible for this interneuronal survival are not well understood...

2017
Juan Ignacio Romero Mariana Inés Holubiec Tamara Logica Tornatore Stéphanie Rivière Eva-Maria Hanschmann Rodolfo Alberto Kölliker-Frers Julia Tau Eduardo Blanco Pablo Galeano Fernando Rodríguez de Fonseca Christopher Horst Lillig Francisco Capani

The general disruption of redox signaling following an ischemia-reperfusion episode has been proposed as a crucial component in neuronal death and consequently brain damage. Thioredoxin (Trx) family proteins control redox reactions and ensure protein regulation via specific, oxidative posttranslational modifications as part of cellular signaling processes. Trx proteins function in the manifesta...

2014
Prabhu Ramamoorthy Honglian Shi

INTRODUCTION Pyramidal (glutamatergic) neurons and interneurons are morphologically and functionally well defined in the central nervous system. Although it is known that glutamatergic neurons undergo immediate cell death whereas interneurons are insensitive or survive longer during cerebral ischemia, the protection mechanisms responsible for this interneuronal survival are not well understood....

2015
Baixiong Zhao Hongyu Quan Teng Ma Yanping Tian Qiyan Cai Hongli Li Bing Yan

Chronic cerebral hypoperfusion is believed to cause white matter lesions (WMLs), leading to cognitive impairment. Previous studies have shown that inflammation and apoptosis of oligodendrocytes (OLs) are involved in the pathogenesis of WMLs, but effective treatments have not been studied. In this study, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), a chloride (Cl-) channel blocker, w...

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