Oxygen uptake (VO2) reflects the rate of aerobic regeneration of high-energy phosphate compounds (primarily adenosine triphosphate [ATP]). Since lactate increase is thought to result from an inadequate rate of aerobic ATP regeneration, it might be expected that lactate increase would be associated with a delayed attainment of steady state for VO2 in response to constant load exercise. Similarly...

Renal cell carcinoma (RCC) represents the sixth most frequently diagnosed cancer in men and is asymptomatic, being detected mostly incidentally. The apparition of symptoms correlates with advanced disease, aggressive histology, poor outcomes. development Surface-Enhanced Raman Scattering (SERS) technique opened way for investigating detecting small molecules, especially biological liquids such ...

Background: Autism spectrum disorder (ASD) is a group of early-onset neurodevelopmental disorders. However, there no valuable biomarker for the early diagnosis ASD. Our large-scale and multi-center study aims to identify metabolic variations between ASD healthy children investigate differential metabolites associated pathogenic mechanisms. Methods: One hundred seventeen autistic 119 were recrui...

Repair replication of DNA in cells exposed to UV, X-rays, or chemical carcinogens involves incorporation of both purine and pyrimidine precursors. Previous reports stating that purines are not involved in repair must be due to insufficient resolution in the reported experiments. Hypoxanthine was more efficiently incorporated by repair replication than other precursors such as adenine, deoxyaden...

The use of a sensitive double-beam spectrophotometer and modifications in enzymatic assay techniques permitted the measurement of adenine nucleosides in extracts of canine left ventricle. In hearts not subjected to left coronary occlusion, adenosine content averaged 0.32 ± 0.04 (SE) nmole/g, increasing to an average of 1.82 ± 0.21 (SE) nmole/g after 15 seconds of coronary occlusion. The myocard...