نتایج جستجو برای: hypothyroxinemia

تعداد نتایج: 201  

Journal: :Endocrine development 2007
Daniel Glinoer

The main change in thyroid function associated with the pregnant state is the requirement of an increased production of thyroid hormone that depends directly upon the adequate availability of dietary iodine and integrity of the glandular machinery. In healthy pregnant women, physiological adaptation takes place when the iodine intake is adequate, while this is replaced by pathological alteratio...

Journal: :The Journal of clinical investigation 1997
J R Martínez-Galán P Pedraza M Santacana F Escobar del Ray G Morreale de Escobar A Ruiz-Marcos

The most severe brain damage associated with thyroid dysfunction during development is observed in neurological cretins from areas with marked iodine deficiency. The damage is irreversible by birth and related to maternal hypothyroxinemia before mid gestation. However, direct evidence of this etiopathogenic mechanism is lacking. Rats were fed diets with a very low iodine content (LID), or LID s...

Journal: :The Journal of clinical endocrinology and metabolism 2004
F Vermiglio V P Lo Presti M Moleti M Sidoti G Tortorella G Scaffidi M G Castagna F Mattina M A Violi A Crisà A Artemisia F Trimarchi

Over a period of almost 10 yr, we carried out a prospective study of the neuropsychological development of the offspring of 16 women from a moderately iodine-deficient area (area A) and of 11 control women from a marginally iodine-sufficient area (area B) whose thyroid function had been monitored during early gestation. Attention deficit and hyperactivity disorder (ADHD) was diagnosed in 11 of ...

Journal: :European journal of endocrinology 2014
Lluís Vila Inés Velasco Stella González Francisco Morales Emilia Sánchez Sara Torrejón Berta Soldevila Alex Stagnaro-Green Manuel Puig-Domingo

There is a well-known controversy among scientific societies regarding the recommendation to screen for thyroid dysfunction (TD) during pregnancy. Although several studies have shown an association between maternal subclinical hypothyroidism and/or hypothyroxinemia with obstetric problems and/or neurocognitive impairment in the offspring, there is only limited evidence on the possible positive ...

Journal: :Cerebral cortex 2014
D Navarro M Alvarado B Morte D Berbel J Sesma P Pacheco G Morreale de Escobar J Bernal P Berbel

Maternal thyroid hormones (THs) are essential for normal offspring's neurodevelopment even after onset of fetal thyroid function. This is particularly relevant for preterm children who are deprived of maternal THs following birth, are at risk of suffering hypothyroxinemia, and develop attention-deficit/hyperactivity disorder. Expression of neocortical Ca(2+)/calmodulin kinase IV (Camk4), a geno...

Amir Mohammad Armanian Awat Feizi, Behzad Barekatain Nima Salehimehr, Roya Kelishadi,

Background: Thyroid function disorders, particularly congenital hypothyroidism (CHT), are important endocrine dysfunctions associated with permanent morbidities. CHT is more prevalent among preterm low-birth-weight neonates compared to term infants with normal weight. Methods: This prospective cohort study was conducted on 126 very-low-birth-weight (VLBW) neonates referred to the neonatal inten...

Introduction: Physiological changes during pregnancy affect thyroid function and also free thyroxine (FT4) assay methods. These impacts make immunoassays unreliable for detecting hypothyroxinemia during pregnancy. Due to pregnant women’s adequate consumption of iodine in Iran, reference ranges of FT4 needs to be obtained for this group. Materials and Methods: A total of 1077 Iranian pregnant wo...

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