Gitelman syndrome is an inherited renal tubular disorder characterized by hypokalemic metabolic alkalosis. It is distinguished from other hypokalemic tubulopathies, such as Bartter syndrome, by the presence of both hypomagnesemia and hypocalciuria. We report a case of Gitelman syndrome in a 10-year-old girl who presented for examination of persistent unexplained hypokalemia. She had no severe c...

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive syndrome that affects the tight junction proteins claudin-16 and claudin-19 in the thick ascending limb. In patients with claudin-19 mutations, additional symptoms such as visual impairment and other ophthalmologic findings are expected. In this report, we present a seven-year-old girl with polyur...

The periparturient cow undergoes a transition from non-lactating to lactating at calving. The animal is tremendously challenged to maintain calcium homeostasis. Those that fail can develop milk fever, a clinical disorder that is life threatening to the cow and predisposes the animal to a variety of other disorders. Guidelines for monitoring the incidence of hypocalcemia and methods for treating...

GINN, H. EARL, AND LINDA L. SHANBOUR. Phosphaturia in magnesium-dejcient rats. Am. J. Physiol. 2 12(6) : 1347-1350. rg67.-The effect of magnesium deficiency on urinary phosphate excretion was studied in rats rendered magnesium deficient by diet. Increased urinary phosphate excretion was observed. Tubular maximum reabsorption (Tm) of inorganic phosphate was lower in magnesium-deficient (0.9 =t 0...

A case of methadone-induced torsades de pointes is presented to demonstrate clinical features that predispose patients to this serious cardiac arrhythmia. A patient who was receiving methadone maintenance treatment for heroin addiction presented to the hospital with dizziness and near-syncope. He was taking a relatively high dose of methadone but was not taking any concomitant cytochrome P450 i...

Magnesium is the fourth-most abundant cation in the human body and the second-most abundant intracellular cation after potassium. Magnesium is pivotal in the transfer, storage, and utilization of energy as it regulates and catalyzes more than 300 enzyme systems. Hypomagnesemia may thus result in a variety of metabolic abnormalities and clinical consequences. It results from an imbalance between...

Objective: The purpose of this study is to assess the prevalence hypomagnesemia among COPD patients (COPD). Study design: A cross sectional study. Place and duration study: I have been offered a position in Medicine & Pulmonology Department at Nishtar Hospital Multan, Pakistan, which will begin March 2016 remain until February 2018. Methodology: non-probabilistic sequential sampling techniq...

BACKGROUND In recent years, digoxin use has been on the decline, with decreased incidence of digoxin toxicity. Hence, digoxin toxicity, when it occurs, remains an elusive diagnosis to emergency physicians. OBJECTIVE To present a case of digoxin toxicity with normal levels of digoxin and serum potassium, but with severe hypomagnesemia. CASE REPORT A 66-year-old woman presented with junctiona...