The aim of the work was to determine antidiabetic effect a sitagliptin and aminoguanidine combination in rats with experimental diabetes mellitus. Materials methods. study carried out on male Wistar C57BL/KsJ-db/db mice. According models used, it divided into 4 series, which alloxan, steroid-induced (dexamethasone) streptozotocin-nicotinamide-induced mellitus (DM) were formed, respectively, rat...