Molecular identification of affected alleles in the index family with rare mutation(s) and/or interaction(s) is an important prerequisite toward a proper genetic counseling. In Thailand, where more than 30% of the populations are heterozygotes for either α or β thalassemia mutation(s). More than 60 different thalassemia syndromes resulting from the interactions of these heterogeneous alleles ha...

During our study of recording auditory evoked potentials in protein-calorie malnutrition in infants and young children (1), we came across a few cases of anaemia. The heamatological investigationsincluding haemogram, showed that, of the five cases, two had megaloblastic anaemia, two had microcytic hypochromic and one had severe aplastic anaemia. Such neurological complications of various types ...

Mice carrying two mutant genes at the f locus on chromosome 1 3 have severe anemia during fetal development, characterized by hypochromic and microcytic red blood cells laden with many iron granules. Ultrastructural studies reveal that the cxcessive nonheme iron accumulated in mutant ( f/f ) fetal erythrocytes is present within mitochondria, similar to those seen in human sideroblastic anemia. ...

OBJECTIVES This study aimed to detect α- and β-thalassaemia mutations in the Jino ethnic minority population of Yunnan Province, Southwest China. DESIGN A total of 1613 Jino adults were continuously recruited from February 2012 to April 2012. Fasting venous blood samples were obtained to determine haematological variables. Haemoglobin analysis was conducted using high-performance liquid chrom...

Introduction: Hematology reference range provides valuable information for the correct interpretation of results for proper diagnosis and treatment. Previous studies have shown that hematology reference range may vary in people of various continents. Method: From 95,501 subjects a normal 500 females and 500 male Kuwaiti fulfilling the criteria of normal individuals were chosen in this study fro...

A number of factors have been shown to limit the response to recombinant human erythropoietin (r-HuEPO). One major factor appears to be an inadequate iron supply to the bone marrow. Erythropoiesis is dependent upon a continuous supply of iron to the bone marrow. The rate at which iron can be drawn from existing stores may easily limit the rate of delivery for haemoglobin synthesis. This results...