A recent literature search of the pertinent publications in the field revealed that there is poor evidence that would support surgical intervention in patients with Adolescent Idiopathic Scoliosis (AIS). With complications estimated to exceed 50% over a lifetime, surgical intervention is unwarranted in the 'Adolescent Idiopathic Scoliosis' AIS population. In the relatively benign population of ...

Idiopathic scoliosis occurs in 3% of individuals and has an unknown etiology. The objective of this study was to identify rare variants that contribute to the etiology of idiopathic scoliosis by using exome sequencing in a multigenerational family with idiopathic scoliosis. Exome sequencing was completed for three members of this multigenerational family with idiopathic scoliosis, resulting in ...

INTRODUCTION We assessed clinical and etiological association between vestibular pathology and idiopathic scoliosis concerning seven members of three families with idiopathic scoliosis. CASE PRESENTATION The families were referred to neurotology center for evaluation of balance problems. Patients were evaluated thorough anamnesis to relevant vestibular and audiological studies in addition to ...

STUDY DESIGN Clinical, radiological, and genetic determination of zygosity of twin pairs from the Danish Twin Registry who self-reported having adolescent idiopathic scoliosis (AIS). OBJECTIVE To establish concordance rates of AIS. SUMMARY OF BACKGROUND DATA The etiology of and the true mode of inheritance of AIS remain unclear. Studies on concordance in twin pairs provide a basis for analy...

Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from...

Background The correlation between idiopathic scoliosis and cavus foot has previously been reported, and has been ascribed to possible lesions related to muscular imbalance influenced by the central nervous system. This study assessed the rate of Pes cavus in scoliotic children. Two groups of patients were compared: those with idiopathic scoliosis and a control group without idiopathic scoliosis.

Results Review of the completed urinalyses revealed a trend towards elevated histamine, elevated norepinephrine and decreased serotonin in the AIS patients as compared to non-scoliotics. Since these neurotransmitters are typically expressed in specific cortical areas, this pattern of imbalance may manifest as a functional hemisphericity, causing asymmetrical efferent responses to peripheral, af...

AIM Primary care practitioners should screen young adolescent patients for idiopathic scoliosis and refer those who could benefit from bracing to prevent curve progression and the need for surgery. Adolescents without a regular source of primary care may be at higher risk for not having their scoliosis diagnosed in time to benefit from bracing. We sought to determine whether adolescents with id...

BACKGROUND Health professionals (HPs) are likely to encounter adolescent idiopathic scoliosis (AIS) patients. Best practice dictates that early detection leads to better decision making regarding optimal management. The aim of our study was to appraise the basic knowledge, evaluation and management skills concerning AIS care among family physicians, pediatricians, chiropractors, and physiothera...

Although, there is no generally accepted scientific theory for the etiology of adolescent idiopathic scoliosis (AIS), the relative anterior spinal column overgrowth has been postulated as a mechanism of AIS progression by many morphological studies. The normal spinal growth involves both kinds of ossification: endochondral and membranous ossification. Considering the uncoupled anterior-posterio...