Intravenous immune globulin (IVIG) has proved beneficial for severe immunologically related cutaneous adverse reactions. We report a child with severe antiepileptic drug hypersensitivity syndrome who was successfully treated with IVIG. IVIG should be considered in the pharmacologic armamentarium of severe antiepileptic drug hypersensitivity syndrome. antiepileptic drugs, hypersensitivity, immun...

‘Drug Induced Hypersensitivity Syndrome’ (DiHS) or Rash with Eosinophilia and Systemic Symptoms’ (DRESS) syndrome is a life threatening, delayed type drug hypersensitivity reaction. This characterized by fever, skin rash, lymphadenopathy, hematological abnormalities visceral involvement liver the most frequently involved organ. Liver mostly presented as acute anicteric hepatitis elevated enzyme...

Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral toler...

Management of corticosteroid (CS) hypersensitivity is not easy, and the choice of an alternative CS is difficult, owing to the high frequency of cross-reactions. Deflazacort has been reported to be a safe alternative in subjects with CS hypersensitivity (1), and reports of deflazacort hypersensitivity are rare (2–7). Here, we report a difficult-to-manage case of systemic allergic dermatitis cau...

T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmaco...

Background Drug desensitization is the induction of temporary clinical unresponsiveness todrug antigens to which patients have presented severe hypersensitivity reactions (HSR). Rapid desensitization in patients suffering immediate hypersensitivity reactions with chemotherapeutic agents and monoclonal antibodies have been widely described and have shown to be successful. Non-immediate hypersens...

OBJECTIVE Hypersensitivity to aprotinin is low (1-3%) but more likely with re-exposure. The manufacturer issued a black box warning which lists aprotinin re-exposure within 1 year of prior exposure as a contraindication. We investigated the temporal relationship between re-exposure interval and hypersensitivity in children. METHODS With Human Research Review Board approval, charts of all pati...

food allergy is a common disorder especially in the first years of life. strict avoidance of the responsible food is the most effective therapeutic measure so far. but this continuous vigilance could be stressful for the patient and family and decreases their quality of life (qol). this survey was designed to evaluate the impact of ige-mediated food allergy on parental qol in iranian patients a...

two independent experiments were conducted with broilers to determine the effect of threonine and vitamin a on immune system. in first experiment, dietary treatments contained 0.8%, 0.87%, 0.94 % and 1.01 % total threonine. in second experiment, diets were as follows: basal diet without vitamin a; basal diet plus 1500 iu/kg vitamin a; basal diet plus 6250 iu/kg vitamin a; basal diet plus 11000 ...

Introduction: In collaboration with the Department of Rheumatology, Allergy and Immunology, our study aims to review outcomes propose an improved workflow for management patients prior hypersensitivity reactions iodinated contrast media (ICM). Method: Outpatients coming contrast-enhanced computed tomography (CECT) were stratified into 3 categories (definite, unconfirmed inaccurate) based on lik...