Chlamydia pneumoniae has been shown to accelerate atherosclerotic lesion development in hyperlipidemic animals. This study showed that C. pneumoniae did not accelerate lesion development in mice if a high-fat/high-cholesterol diet was started after infection, indicating that C. pneumoniae is a co-risk factor with hyperlipidemia for cardiovascular disease.

Condensed abstract: We investigated the molecular mechanism of nicotine-accelerated atherosclerosis in hyperlipidemic LDLR-/mouse model. Our findings reveal a novel mechanism of nicotine in atherogenesis. Nicotine directly activates macrophages via the nicotinic acetylcholine receptors, inducing multiple downstream events, subsequently resulting in NFkB-mediated inflammation in the arterial wal...

Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder in Western societies. In a recent report (Dallinga-Thie, G.M., X.D. Bu, M. van Linde-Sibenius Trip, J.I. Rotter, A.J. Lusis, and T.W.A. de Bruin. J. Lipid Res., 1996, 36:136-147) we have studied three restriction enzyme polymorphisms: XmnI, and MspI sites 5' of the apo AI gene and SstI site in the 3' untranslated region o...

P.J. Westenend, MD, Department of Pathology, University Hospital Nijmegen, PO Box 9101, NL-6500 HB Nijmegen (The Netherlands) Dear Sir, The role of lipids in the pathogenesis and progression of glomerulosclerosis has become a focus ofrecent investigation. Some studies suggest that the development of glomerulosclerosis is analogous to that of atherosclerosis [1]. This hypothesis is in part based...

Title: 1 H-NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters 1 H-NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters, This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manus...

Purpose – Reducing fat intake or inhibiting fat absorption is a useful solution for blood lipid reduction. It is shown that there are some proteins in wheat germ with pancreatic lipase inhibiting properties that have hypolipidemic effects. This paper aims to evaluate the possible beneficial effects of a daily intake of 30 g of raw wheat germ in a population of Iranian hyperlipidemic subjects wi...

OBJECTIVE Atherosclerosis requires migration of monocytes to the arterial intima, with subsequent differentiation into foam cells. We showed previously that the scavenger receptor CD36 contributes to the activation of Vav family guanine nucleotide exchange factors (Vavs) in aortae from hyperlipidemic apoE-null mice and that oxidatively modified low-density lipoprotein induced CD36-dependent act...

Proatherogenic, hyperlipidemic states demonstrate increases in circulating ligands for scavenger receptor CD36 (eg, oxidized low-density lipoprotein [oxLDL]) and the Na/K-ATPase (eg, cardiotonic steroids). These factors increase inflammation, oxidative stress, and progression of chronic kidney disease. We hypothesized that diet-induced obesity and hyperlipidemia potentiate a CD36/Na/K-ATPase-de...