This study investigated the role of heme oxygenase (HO)-1 in the cardiac tissue injury of acute ischemia/reperfusion (I/R) in diabetic streptozotocin (STZ)-induced hyperglycemic rats. The effects of 1) hemin, an inducer of HO expression and activity, and 2) zinc protoporphyrin IX (ZnPP-IX), an inhibitor of HO activity, have also been investigated on the tissue injury by I/R and some mediators r...

background: type 2 diabetes mellitus with hyperlipidemia is a common disease. conventional anti-hyperglycemic and anti-hyperlipidemic drugs have limited efficacies and important side effects, so that alternative agents are needed. previous studies suggest that fiber-free artichoke (cynara scolymus l.) leaf extract may have anti-hyperglycemic and anti-hypercholesterolemic effects in hypercholest...

objective(s) pde3 has a functional role in insulin secretion and action. we investigated the metabolic effects of new synthetic pde3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. materials and methods the test compound or solvent was injected subcutaneously to mice, for 7 days. on day 8, blood and liver samples were obtained. in hyperglycemic rat, 0.5 g/kg glucose with or w...

Objectives The association between hyperglycemia at admission and COVID-19 severity in-hospital mortality is an area of active medical research. Our study aims to explore this across diabetics hyperglycemic patients while keeping normoglycemic as control. Methods This retrospective cohort involved a total 90 with confirmed diagnosis infection. Patients were divided into three equal groups based...

Diabetic ketoacidosis is the complicationof Diabetes mellitus, which can result due to extreme hyperglycemia and ketonaemia. This condition prevalent among patients with untreated diabetes ordrug incompliance. Hyperglycemic hyperosmolar state clinically be presented episodes of seizures high blood sugar levels absence ketones has low incidence rate. A 55 year old male patient episode seizure, f...