s | 33 Abstract It was reported the unconjugated bilirubin may be associated with neurotoxicity in the developing nervous system. And it is also reported that neonatal hyperbilirubinemia might be a vulnerability factor for the development of mental disorders. Individuals with schizophrenia show a significantly higher frequency of hyperbilirubinemia relative to patients with other psychiatric di...

s | 33 Abstract It was reported the unconjugated bilirubin may be associated with neurotoxicity in the developing nervous system. And it is also reported that neonatal hyperbilirubinemia might be a vulnerability factor for the development of mental disorders. Individuals with schizophrenia show a significantly higher frequency of hyperbilirubinemia relative to patients with other psychiatric di...

Featured Article: Fossati P, Prencipe L, Berti G. Use of 3,5-dichloro-2-hydroxybenzenesulfonic acid/4aminophenazone chromogenic system in direct enzymic assay of uric acid in serum and urine. Clin Chem 1980;26:227–31. Our 1980 report in Clinical Chemistry described an improved chromogenic detection system that, coupled with the enzyme oxidation of uric acid, led to a direct method for assaying ...

Ezetimibe (EZE) selectively blocks intestinal cholesterol absorption by interacting with Niemann-Pick C1 Like 1 (NPC1L1). After administration, EZE is extensively metabolized in liver and intestine to its phenolic glucuronide form (EZE-G) by uridine diphosphate glucuronosyltransferases (UGTs), among which UGT1A1 and 1A3 exhibit highest activity. EZE-G is excreted into bile and undergoes extensi...

Despite efforts to eliminate permanent and irreversible brain damage due to bilirubin encephalopathy and kernicterus, these conditions continue to accompany us into the third millennium. This phenomenon occurs not only in developing countries with emerging medical systems, but in Westernized countries as well. Comprehensive guidelines to detect newborns with jaundice and treat those in whom hyp...

The erythrocyte sedimentation rate (ESR) test continues to be used as an important tool in many laboratories; either manually or as automated method. When automation is applied in clinical laboratories, it is imperative that reliable methods for calibration and appropriate control materials are available for monitoring the accuracy and precision of the results generated. But when the commercial...

Despite efforts to eliminate permanent and irreversible brain damage due to bilirubin encephalopathy and kernicterus, these conditions continue to accompany us into the third millennium. This phenomenon occurs not only in developing countries with emerging medical systems, but in Westernized countries as well. Comprehensive guidelines to detect newborns with jaundice and treat those in whom hyp...

Despite efforts to eliminate permanent and irreversible brain damage due to bilirubin encephalopathy and kernicterus, these conditions continue to accompany us into the third millennium. This phenomenon occurs not only in developing countries with emerging medical systems, but in Westernized countries as well. Comprehensive guidelines to detect newborns with jaundice and treat those in whom hyp...