The aim of this paper is to define hyper-Leonardo hybrinomials as a generalization the Leonardo Pisano and examine some their properties such recurrence relation, summation formula generating function. Another introduce hyper hybrid-Leonardo numbers.

We have recently introduced a hyper-heuristic genetic algorithm (hyper-GA) with an adaptive length chromosome which aims to evolve an ordering of low-level heuristics so as to find good quality solutions to given problems. The guided mutation and crossover hyper-GA, the focus of this paper, extends that work. The aim of a guided hyper-GA is to make the dynamic removal and insertion of heuristic...

Hyper-heuristics are a class of high-level search methods used to solve computationally difficult problems, which operate on a search space of low-level heuristics rather than solutions directly. Previous work has shown that selection hyper-heuristics are able to solve many combinatorial optimisation problems, including the multidimensional 0-1 knapsack problem (MKP). The traditional framework ...

Hyper-heuristics are aimed at providing a generalized solution to optimization problems rather than producing the best result for one or more problem instances. This paper examines the use of evolutionary algorithm (EA) selection hyper-heuristics to solve the offline one-dimensional bin-packing problem. Two EA hyper-heuristics are evaluated. The first (EA-HH1) searches a heuristic space of comb...

BACKGROUND The onset of diabetes causes disruption of respiratory epithelial mediators. The present study investigates whether diabetes modifies the epithelium mediated bronchial responses in hyper-reactive airway smooth muscle (ASM) primarily through nitric oxide (NO), cyclooxygenase (COX), and epithelium derived hyperpolarizing factor (EpDHF) pathways. METHODS Experimental model of guinea p...

Background The role of calcium in physiological phenomenona such as sperm acrosome reaction and hyper-activation has been well known. Calcium ionophore A23187 is routinely used for induction of acrosome reaction in mammalians sperm. Therefore, we decided to evaluate the effect of calcium ionophore A23187 on the sperm hyper-active motility patterns. MaterialsAndMethods Ten semen samples from ind...