In a double-blind, randomized study, we have compared the efficacy of transdermal hyoscine in the prevention of nausea and vomiting with placebo in 60 young, ASA I-II patients after middle ear surgery during general anaesthesia. In the placebo group, 27% and 43% of patients suffered from nausea and vomiting, respectively, during the first 24 h after anaesthesia. The corresponding values for bot...

The effects of combined exposure to n-butyl alcohol and n-butyl acetate on rotarod performance and hot plate behaviour in rats and respiratory rate in mice were investigated in the condition of an acute inhalation experiment. Rotarod performance and hot-plate behaviour were tested in rats exposed to various concentrations of n-butyl alcohol, n-butyl acetate and their mixture consisting of 50 Vo...

The clinical efficacy of glycopyrrolate, a synthetic anticholinergic drug, for premedication was compared in a double-blind study with that of atropine or hyoscine in patients anaesthetized with diethyl ether. The antisialogogue actions of the three drugs were similar. Glycopyrrolate produced less tachycardia, pyrexia and blurred vision than atropine, and its sedative effect was less than that ...