Alveolar epithelial type II (AT2) cells secrete pulmonary surfactant via lamellar bodies (LBs). Abnormalities in LBs are associated with disorders, including fibrosis. However, high-content screening (HCS) for LB abnormalities is limited by the lack of understanding AT2 cell functions. In present study, we have developed harboring LB-like organelles that proteins. These were more similar to tha...

Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes DDC-Cu with hydroxypropyl beta-cyclodextrin (HP) or sulfobutyl ether (SBE) were prepared and investigated as an approach to enhance the apparent solubility DDC-Cu. F...