Hydroxyethyl starch (HES) has found widespread use to increase the efficiency of granulocyte collection. Although there is some concern about the possible harmful side effects on the donor. such as plasma expansion. these are believed to be shortlived. since the hematocrit returns to baseline by 24 hr. We have used ‘31l-albumin to measure the actual changes in plasma volume in donors who receiv...

Hydrogel systems based on hydroxyethyl starch-polyethylene glycol methacrylate (HES-P(EG)(6)MA) or hydroxyethyl starch methacrylate (HES-MA) were used to assess the protein release behavior. Here, we analyzed the in vitro release of FITC-anti-human antibodies incorporated in either HES-P(EG)(6)MA or HES-MA hydrogel delivery systems in PBS or human serum. In addition, hydrogel disks and micropar...

117 RefeRences 1. Ma PL, Peng XX, Du B, Hu XL, Gong YC, Wang Y, et al. Sources of heterogeneity in trials reporting hydroxyethyl starch 130/0.4 or 0.42 associated excess mortality in septic patients: A systematic review and meta‐regression. Chin Med J 2015;128:2374‐82. doi: 10.4103/0366‐ 6999.163387. 2. Zhu GC, Quan ZY, Shao YS, Zhao JG, Zhang YT. The study of hypertonic saline and hydroxyethyl...

UNLABELLED Hextend is a new plasma volume expander containing 6% hydroxyethyl starch (HES) in a physiologically balanced medium of electrolytes, glucose, and lactate (weight average, molecular weight 670 kDa, molar substitution 0.75). This open-label study was designed to investigate the pharmacokinetic and pharmacodynamic profiles of Hextend in 21 healthy volunteers. We infused Hextend 10 ml/k...

The paper deals with pharmacotherapeutical approaches to decreasing hematocrit in order to improve macro and microcirculation in arteries of lower limbs of type 2 diabetes patients. The study included 37 patients with diabetic angiopathy, all of whom had inoperable changes to arteries. In order to decrease hematocrit and cause haemodilution, we used 10 % solution of hydroxyethyl starch. Indicat...

We compared the effects of hypertonic saline 7.2%/6% hydroxyethyl starch (HSS-HES) and isotonic saline 0.9%/6% hydroxyethyl starch (ISS-HES) on ileal microcirculatory blood flow (MBF) at the initial phase of septic shock. Pigs were anesthetized and mechanically ventilated. Catheters were inserted into right atrium, pulmonary artery, carotid artery, and portal vein for hemodynamic measurements a...

hydroxyethyl starch (HES) 130/0.4 in 9,587 patients and a meta-analysis evaluating HES 130/0.42 in 804 patients, HES 130 was shown to increase mortality and the need for renal replacement therapy (RRT) [1]. In the largest included trial of the meta-analysis, the Crystalloid versus Hydroxyethyl Starch Trial (CHEST) with 7,000 ICU patients [2], HES 130/0.4 increased the need for RRT despite a low...

we reported were in compliance with the Victoria DHS Guidelines for DES, which fall within the FDA guidelines, and therefore do not constitute ‘off-label’ use. With respect to the protocol developed in the Geelong Hospital, we assumed that the DES was a ‘high-risk lesion’ in the coronary circulation and devised a treatment regimen to reduce the risk of coronary occlusion while at the same time ...

Post-thaw testing of large units of red cells frozen with 14% hydroxyethyl starch (HES) indicates 97-98s of the cells are recovered and about 85% are stable in saline (1). The quantity of supernatant hemoglobin present in such units at thaw is generally near 450-550 mgs. We have been unable to obtain consistent results which reveal a substantial improvement over these values, This quantity of f...