To cure SARS-CoV-2 infection, the repurposing of conventional antiviral drugs is currently advocated by researchers, though their action not very effective. The present study, based on in silico methods, was intended to increase therapeutic potential drugs: hydroxychloroquine (HCQ), favipiravir (FAV), and remdesivir (REM) using curcuminoids like curcumin (CUR), bisdemethoxycurcumin (BDMC), deme...

OBJECTIVE SLE is associated with increased risk of diabetes mellitus. Treatment for SLE requires high-dose glucocorticoids that may worsen glucose homoeostasis. HCQ can reduce diabetes risk in RA. This study aimed to investigate the association of HCQ use and diabetes mellitus risk in SLE patients. METHODS This nationwide, population-based cohort study was conducted using the Taiwan National ...

Reductive amination plays a paramount role in the synthesis of amines. It is often proposed as more ecofriendly process than traditional SN2-type reactions amines it avoids toxic alkylation reagents such alkyl halides. This work demonstrates versatility reductive reaction via hydroxychloroquine (HCQ), one most renowned pharmaceuticals during this coronavirus pandemic. The novel green strategy b...

Abstract Background/Aims Hydroxychloroquine (HCQ) is used widely in the management of rheumatic diseases and considered to be generally well tolerated. HCQ ocular toxicity a dose- time-related reaction. The Royal College Ophthalmologists (RCOphth) noted low rate drug discontinuation as result baseline testing (< 4%) that prevalence data for was based on treatment duration >5 years...

Background: Antimalarials have been associated with QT prolongation in COVID19 patients but are generally safe rheumatologic disease. Objectives: Aim of the study was to compare prevalence QTc between and Systemic Lupus Erythematosus (SLE) treated hydroxychloroquine (HCQ). Methods: We included consecutive SARS-CoV-2 infection confirmed by nasopharyngeal swab taking HCQ for SLE. A prolonged defi...

Background: COVID-19 has led to the demand for finding effective antiviral agents. Preliminary experiments showed Umifenovir inhibit replication in vivo. There is limited data on clinical efficacy of COVID-19-infected pneumonia. Therefore, we aimed evaluate this medication based findings.
 Methods: The present study was designed investigate advantages and disadvantages compared empirical t...

BACKGROUND Chloroquine (CQ) and hydroxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Both drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retinopathy. Established risk factors are duration and dosage of treatment while the involvement of genetic factors contributing ...

OBJECTIVE To evaluate the effect of different concomitant disease modifying antirheumatic drugs (DMARDs) on the persistence with antitumour necrosis factor (anti-TNF) therapies in patients with rheumatoid arthritis (RA). METHOD This analysis included 10 396 patients with RA registered with the British Society for Rheumatology Biologics Register, a prospective observational cohort study, who w...

Objective. We hypothesized that initiation of a new disease-modifying antirheumatic drug (DMARD) for treatment of rheumatoid arthritis (RA) would decrease the use of corticosteroids, nonsteroidal antiinflammatory drugs (NSAIDs), and narcotics.Methods. Using administrative databases, we assembled 4 retrospective cohorts of RA patients (1998-2005) and identified 5 groups initiating DMARD regimens...