INTRODUCTION Benzodiazepine treatment of life-threatening gamma-hydroxybutyrate (GHB) withdrawal is frequently unsatisfactory. Animal studies suggest strongly that treatment with GABA(B) agonists, such as baclofen, will be a more effective strategy. METHODS A case report from the medical intensive care unit (ICU) of the university tertiary care hospital. RESULTS A 61-year-old woman was admi...

Case A 35-year-old man with no significant medical history presented to a university ED complaining of anxiety. tremors and insomnia. The patient denied use of common street drugs or tobacco. He admitted to social weekend alcohol consumption, but had not been drinking during the preceding 2 weeks. His vital signs were: temperature 37.2OC, pi~lse 105/min. respirations 161 min. blood pressure 148...

The divalent cation ionophore A23187 has been used to examine the steady state kinetics of energy-dependent Ca2+ uptake with /3-hydroxybutyrate as oxidizable substrate, and these results have been compared to the kinetic parameters obtained with succinate as the available energy source. The kinetics are sigmoidal with the free Ca*+ concentration at half-maximal respiratory stimulation (K,,,,) e...

The divalent cation ionophore A23187 has been used to examine the steady state kinetics of energy-dependent Ca2+ uptake with /3-hydroxybutyrate as oxidizable substrate, and these results have been compared to the kinetic parameters obtained with succinate as the available energy source. The kinetics are sigmoidal with the free Ca*+ concentration at half-maximal respiratory stimulation (K,,,,) e...

BACKGROUND A low-carbohydrate diet (LCD) achieves good glycemic control in type 2 diabetes (T2DM) compared with a high-carbohydrate diet. With respect to energy metabolism, acute metabolic responses to high-carbohydrate meals (HCMs) have not been determined in LCD patients with T2DM. SUBJECTS AND METHODS We enrolled 31 subjects with T2DM (mean age: 62 yrs, mean hemoglobin A1c level: 6.9%), of...

Intermittent fasting has been demonstrated to protect against Alzheimer's disease (AD), however, the mechanism is unclear. Histone acetylation and lipoprotein lipase (LPL) are involved in AD progression. Importantly, LPL has been documented to be regulated by histone deacetylases (HDACs) inhibitors (increase histone acetylation level) in adipocyte and mesenchymal stem cells, or by fasting in ad...