The effect of stabilizer type (small molecule vs. polymeric) and the amount of micellar solubilized drug on Ostwald ripening of nanosuspensions was investigated. Indomethacin nanosuspensions were prepared with small molecule stabilizers (sodium lauryl sulfate (SLS) and Dowfax 2A1 (DF)) and a polymeric stabilizer (hydroxypropyl methyl cellulose (HPMC)). Two different drug:stabilizer ratios were ...

Hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) are modified cellulose dietary fibers that generate viscous solutions in the gastrointestinal (GI) tract. This study assessed the effects of high viscosity (HV) HPMC, ultra-HV (UHV) HPMC, and medium viscosity MC on postprandial glucose and insulin responses in overweight and obese men and women (n = 50). After overnight fasts, subject...

This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

The goal of this investigation was to determine the effectiveness hydrophilic polymers in preparing a solid dispersion enhance solubility and dissolution poorly water-soluble drugs, such as curcumin. In order prepare dispersion, curcumin uniformly distributed polymeric matrix polyethylene glycol (PEG 6000), hydroxypropyl methyl cellulose (HPMC E5), polyvinyl pyrrolidine (PVP K30), bovine serum ...

Froth flotation is an operation currently used for the recovery of Cu from pyrometallurgical smelting slags due its simple and relatively low operational costs. While it has been utilized many decades, may be necessary to develop strategies that improve slags, as unprecedented increase in demand made industrial waste side streams economically relevant sources metals. This study presents a novel...

Aib α-Aminoisobutyric acid or Cα-methylalanine (αMe)Phe Cα-methylphenylalanine (αMe)Val Cα-methylvaline BOP (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium CIP 2-Chloro-1,3-dimethylimidazolidium phosphate Db z g Cα,α-dibenzylglycine Deg Cα,α-diethylglycine Dφg Cα,α-diphenylglycine Dp n g Cα,α-di-n-propylglycine EDC 1-(3-Dimethylamino)propyl-3-ethylcarbodiimide HATU 2-(1H-7-aza-1,2,3-benzot...

The dominant onion bulb glutathione S-transferases (GSTs) (named as GSTc, GSTd and GSTe) were separated by DEAE cellulose column chromatography, and the inhibitory interactions of glutathione (GSH) derivatives (S-methyl GSH, S-propyl GSH, S-butyl GSH, and S-hexyl GSH), four coumarins (coumarin, 7-hydroxy coumarin, esculetin and scopoletin) were tested with theses GSTs. The activities of GSTs we...

The title compound, C(15)H(16)N(2)O(2)·H(2)O, was synthesized via the alkyl-ation of 3-hydroxy-methyl-idene-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one with n-propyl iodide in the presence of sodium hydroxide. The organic mol-ecule and the water mol-ecule both lie on a crystallographic mirror plane. In the crystal structure, inter-molecular O-H⋯O and O-H⋯N hydrogen bonds link the components i...