The hydrophobic mismatch between the lipid bilayer and integral membrane proteins has well-defined effect on mechanosensitive (MS) ion channels. Also, membrane local bending is suggested to modulate MS channel activity. Although a number of studies have already shown the significance of each individual factor, the combined effect of these physical factors on MS channel activity have not been in...

Abstract N‐ or C‐methylation in natural and synthetic cyclic peptides can increase membrane permeability, but it remains unclear why this happens some cases not others. Here we compare three‐dimensional structures for from six families, including isomers differing only the location of an Cα‐methyl substituent. We show that a single methyl group increases permeability when connects expands hydro...

Abstract We fabricated semitransparent and stretchable hybrid Ag-polytetrafluoroethylene (PTFE) conductors on a polyurethane (PU) substrate for use in high-performance wearable self-cleaning sensors. The highly conductive Ag metal PTFE polymer matrix were cosputtered, embedding the self-formed matrix. Depending cosputtering RF DC power ratio, Ag-PTFE showed sheet resistance of 3.09–17.23 Ω/squa...

OBJECTIVE To evaluate the clinical outcomes with the use of a dual-porosity expanded polytetrafluoroethylene implant for midfacial rejuvenation. DESIGN An institutional review board-approved retrospective chart review was conducted of all patients who underwent implantation with the dual-porosity expanded polytetrafluoroethylene implant between 2001 and 2005. RESULTS A total of 170 patients...

Polytetrafluoroethylene can be considered as a model for calorimetric studies of complex systems with thermodynamics transitions at ambient temperature. This polymer exhibits two phase transitions of different nature at 292 K and 303 K. We show that sensitive accalorimetry measurements allow us to study the thermodynamic behaviour of polytetrafluoroethylene when it is brought out of thermodynam...

BACKGROUND Channel proteins like the engineered FhuA Δ1-159 often cannot insert into thick polymeric membranes due to a mismatch between the hydrophobic surface of the protein and the hydrophobic surface of the polymer membrane. To address this problem usually specific block copolymers are synthesized to facilitate protein insertion. Within this study in a reverse approach we match the protein ...

Hydrophobic stop-transfer sequences generally serve to halt the translocation of polypeptide chains across the endoplasmic reticulum membrane and become integrated as transmembrane alpha-helices. Using engineered glycosylation sites as topology reporters, we show that the length of the nascent chain between a hydrophobic segment and the carboxy terminus of the protein can affect stop-transfer e...