Introduction: Our previous studies showed that hydroalcoholic extract of leaf of Vitis vinifera relaxes the phenylephrine-induced contraction in rat thoracic aorta. This effect was dependent on endothelial integrity and NO-cGMP system. The vasorelaxant effect of extract was much lesser on KCl-induced contraction. We, therefore, postulated that K+ channels are involved. The main aim of the prese...

Background: Thymus persicus is one of the Iranian endemic medicinal plants, that its decoction and various products have plenty of food and pharmaceutical uses. Objective: Evaluation of T. persicus products metabolite contains and determination of the best antioxidant, anti-diabetic and anti-Alzheimer extract. Methods: Samples total phenolic, flavonoid and tannin contents were determined by F...

objective: at present, there are many antiepileptic drugs with a wide range of side effects on the human body. it was assumed that zataria multiflora boiss (z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. the aim of the present study was to elucidate the effect of z. multiflora hydroalcoholic extract and its fraction ext...

Background and Purpose: Treatment of life-threatening fungal infections caused by Candida species has become a major problem. Candida spp. are the most important causative agents of candidiasis. Allium tripedale is a medicinal plant that has been traditionally used to treat infections. In the present study, we aimed to determine the chemical compounds and antimicrobial activity of hydroalcoholi...

OBJECTIVE Pinus eldarica (P. eldarica) is one of the most common pines in Iran which has various bioactive constituents and different uses in traditional medicine. Since there is no documented evidence for P. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of P. eldarica bark were investigated in male and female Wistar rats in this study. MATERIALS AND METHO...

OBJECTIVE Oxidative stress plays an important role in the etiology of diabetic complications. Diabetes impairs hippocampus neurogenesis, synaptic plasticity, and learning. The aim of this study was to investigate the effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in STZ-induced diabetic rats' hippocampus. MATERIALS AND METHODS Diabetes induced by 60 mg/kg STZ, i....

it has been reported that rosa damascena hydroalcoholic extract has inhibitory effect at higher concentration but stimulatory action at lower concentrations on ileum. this could be due to the presence of stimulatory components in the extract. r. persica mich. is another species which belongs to rose family but so far there is no report about pharmacological action of its extract. therefore, the...

BACKGROUND Cerebral ischemia causes some disorders in behavioral patterns, including memory disorders and pain, which is due to the production of free radicals. Ferulago angulata, known in Iran as chavir, contains some bioactive compounds having antioxidant and free radical-scavenging properties. OBJECTIVES This study aimed to evaluate the effect of two weeks oral administration of hydroalcoh...

Background Metabolic control is a major concern in preventing diabetic complications. Saffron as a natural source of antioxidants could play a role in alleviating diabetes insults. The aim of this study was to investigate effect of saffron hydroalcoholic extract on metabolic control in type 2 diabetes (T2D) mellitus. Materials and Methods This randomized triple blind study was included 54 T2D...