The antituberculous activity of isoniazid used alone or in combination with streptomycin or para-aminosalicylic acid (PAS) has been established.’ One of the most favorable properties of isoniazid is the low incidence of significant toxicity resulting from its use when doses of 3 to 5 mg. per kilogram per day are administered. Some of the reactions reported include toxic psychosis, convulsions, ...

ABSTRACT. The versatile scaffold, N'-(2-cyanoacetyl)-2-hydroxybenzohydrazide (3) was utilized in the production of new pyridine, chromene and thiazole derivatives as antimicrobial antioxidant agents. synthetic strategy involves treatment precursor 3 with various arylidene-malononitrile 3-aryl-2-cyanoacrylate compounds to furnish substituted pyridines 5 7. interaction salicylaldehyde and/or phen...