A series of mouse-human hybrids was prepared from mouse cells deficient in adenine phosphoribosyltransferase (EC 2.4.2.7) and normal human cells. The hybrids were made in medium containing adenine and alanosine, an antimetabolite known to inhibit de novo adenylic acid biosynthesis. The mouse cells, unable to utilize exogenous adenine, were killed in this medium, but the hybrids proliferated as ...

A status of early series production of the barrel hybrids and modules of the ATLAS Semiconductor Tracker (SCT) is reported. 120 hybrids (with ASIC’s) and 98 modules were fabricated in Japan by the mid. August 2002 and gone through extensive quality assurance tests. Defective channels were found much less than 1% in hybrids and still less than 1% in modules. No increase of defective channels was...

We report herein the design and synthesis of a series of novel imidazo[1,2-a]pyridine amide-cinnamamide hybrids linked via an alkyl carbon chain. All 38 new hybrids were evaluated for their antimycobacterial activity against M. tuberculosis (MTB) H37Rv ATCC 27294 using the microplate Alamar Blue assay (MABA). Although the hybrids are less active than the two reference compounds, the promising a...

Inbred 129/Sv mice were resistant to inoculation of teratocarcinoma cells when preimmunized with (129teratocarcinoma x C3H L-cell) somatic cell hybrids ob tained by fusion with UV-inactivated Sendai virus. Re sistance of DBA/2 mice to the highly malignant L1210 leukemia was also obtained by the use of (L1210 x C3H L-cell) hybrids. That this resistance was specific was sug gested by regular take...

Medicago sativa, alfalfa or lucerne, and M. arborea were considered reproductively isolated until recently. Then, in 2003, an alfalfa genotype was identified that produced a few seeds and progeny with hybrid traits after a large number of pollinations by M. arborea. A derivative of this alfalfa genotype also produced a low frequency of progeny with hybrid traits. Thus, the hybridization barrier...

Genomic selection is an upgrading form of marker-assisted selection for quantitative traits, and it differs from the traditional marker-assisted selection in that markers in the entire genome are used to predict genetic values and the QTL detection step is skipped. Genomic selection holds the promise to be more efficient than the traditional marker-assisted selection for traits controlled by po...

Conspecific rape often increases male reproductive success. However, the haste and aggression of forced copulations suggests that males may sometimes rape heterospecific females, thus making rape a likely, but undocumented, source of hybrids between broadly sympatric species. We present evidence that heterospecific rape may be the source of hybrids between Black-footed and Laysan Albatrosses (P...

Corn is physiologically mature when kernels reach maximum dry weight and are safe from frost. All milky fluid disappears from the kernel, and the black layer, a dark layer of cells, forms near the tip of mature kernels. Most hybrids adapted to Wisconsin reach this stage when kernel moisture decreases to 30–32%, but it may not occur until moisture content decreases to 28% for some early hybrids....

The haplodiploid wasp genus Nasonia is a promising model for studying the evolution of genic incompatibilities due to the existence of interfertile species and haploid males. The latter allows for significantly reducing the sample size required to detect and map recessive dysfunctional genic interactions. We exploited these features to study the genetics of intrinsic hybrid inviability in male ...

Here we tested two possible nonexclusive explanations for the maintenance of a hybrid swarm between Senecio jacobaea and Senecio aquaticus; first, that genotype-by-environment interactions involving water and nutrient clines are involved in hybrid fitness, and second, heterosis in early hybrid generations may provide an initial hybrid advantage that contributes to hybrid persistence. In three c...